Evidence map›Paper›PMID 30683913›Full record

ReviewNature reviews. Neurology2019

Deep brain stimulation: current challenges and future directions.

Andres M Lozano, Nir Lipsman, Hagai Bergman, Peter Brown, Stephan Chabardes, Jin Woo Chang, Keith Matthews, Cameron C McIntyre, Thomas E Schlaepfer, Michael Schulder and 3 more

2 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 645 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
645citing papers in PubMed, 11 pooled it
78.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06303869 narecruitingnot on this mapstarted 2025, after this paper: background citation

Deep Brain Stimulation Motor Ventral Thalamus (VOP/VIM) for Restoration of Speech and Upper-limb Function in People With Subcortical Stroke

TypeinterventionalSponsorJorge Gonzalez-MartinezRan2025 to 2029Enrolled10ConditionsStroke, Brain Disease, Central Nervous System Diseases, Nervous System DiseasesArmsDeep Brain Stimulation (DBS) of the Motor Thalamus
NCT07056348 narecruitingnot on this mapstarted 2022, after this paper: background citation

Chronic Stimulation of the Motor Ventral Thalamus (VOP/VIM) for Motor Control in Humans

TypeinterventionalSponsorJorge Gonzalez-MartinezRan2022 to 2030Enrolled60ConditionsTraumatic Brain Injury, Stroke, Brain Disease, Movement Disorders (Incl Parkinsonism)ArmsDeep Brain Stimulation (DBS) of the Motor Thalamus
3 · Its place in the literature

Who cites it

645 citing papers in PubMed, 11 syntheses or guidelines pooled it, 1,389 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Clinical efficacy of neuromodulation in isolated dystonia: A systematic review of motor function improvement.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Pooled it
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  10. Pooled it
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  12. Trial
  13. Trial
  14. Article
  15. Review
  16. Review
  17. Article
  18. RF Power, BSensors (Basel, Switzerland) · 2026
    Article
  19. Psychiatric consultation outcomes in deep brain stimulation candidacy: clinical and psychosocial correlates from a retrospective cohort.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  20. Review

585 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 12 institutions in 8 countries.

Andres M LozanoDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada. lozano@uhnresearch.ca.
Nir LipsmanDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Hagai BergmanDepartment of Medical Neurobiology, Hadassah Medical School, Jerusalem, Israel.ORCID http://orcid.org/0000-0002-2402-6673
Peter BrownMedical Research Council Brain Network Dynamics Unit, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-5201-3044
Stephan ChabardesDepartment of Neurosurgery, Université Joseph Fourier, Grenoble, France.
Jin Woo ChangDepartment of Neurosurgery, Yonsei University College of Medicine, Seoul, South Korea.
Keith MatthewsDivision of Neuroscience, Ninewells Hospital and Medical School, Dundee, UK.
Cameron C McIntyreDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Thomas E SchlaepferDivision of Interventional Biological Psychiatry, Albert-Ludwigs University, Freiburg, Germany.ORCID http://orcid.org/0000-0003-0612-9692
Michael SchulderDepartment of Neurosurgery, Hofstra Northwell School of Medicine, Hempstead, NY, USA.
Yasin TemelDepartment of Neurosurgery, Maastricht University Medical Center, Maastricht, Netherlands.
Jens VolkmannDepartment of Neurology, University Hospital of Würzburg, Würzburg, Germany.
Joachim K KraussDepartment of Neurosurgery, Hannover Medical School, Hannover, Germany.
University of Toronto · CACase Western Reserve University · USHadassah Medical Center · ILHofstra University · USMaastricht University · NLMedizinische Hochschule Hannover · DENinewells Hospital · GBUniversitätsklinikum Würzburg · DEUniversité Joseph Fourier · FRUniversity of Freiburg · DEUniversity of Oxford · GBYonsei University · KR

Funding

Medical Research Council MC_UU_12024/1
6 · The paper itself

Abstract

The clinical use of deep brain stimulation (DBS) is among the most important advances in the clinical neurosciences in the past two decades. As a surgical tool, DBS can directly measure pathological brain activity and can deliver adjustable stimulation for therapeutic effect in neurological and psychiatric disorders correlated with dysfunctional circuitry. The development of DBS has opened new opportunities to access and interrogate malfunctioning brain circuits and to test the therapeutic potential of regulating the output of these circuits in a broad range of disorders. Despite the success and rapid adoption of DBS, crucial questions remain, including which brain areas should be targeted and in which patients. This Review considers how DBS has facilitated advances in our understanding of how circuit malfunction can lead to brain disorders and outlines the key unmet challenges and future directions in the DBS field. Determining the next steps in DBS science will help to define the future role of this technology in the development of novel therapeutics for the most challenging disorders affecting the human brain.

Indexed as

Deep Brain StimulationBrain DiseasesHumansMental Disorders

Identifiers

PMID30683913
PMCPMC6397644
OpenAlexW2912123407

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.