Evidence map›Paper›PMID 30683769›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2019

Matthew B Nodwell, Hua Yang, Helen Merkens, Noeen Malik, Milena Čolović, Björn Wagner, Rainer E Martin, François Bénard, Paul Schaffer, Robert Britton

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. One-Step Synthesis of [ACS central science · 2024
    Article
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Matthew B NodwellDepartment of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada.
Hua YangLife Sciences Division, TRIUMF, Vancouver, British Columbia, Canada.
Helen MerkensDepartment of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada.
Noeen MalikLife Sciences Division, TRIUMF, Vancouver, British Columbia, Canada.
Milena ČolovićDepartment of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada.
Björn WagnerPharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland; and.
Rainer E MartinMedicinal Chemistry, Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
François BénardDepartment of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada.
Paul SchafferDepartment of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada.
Robert BrittonDepartment of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada rbritton@sfu.ca.
BC Cancer Agency · CARoche (Switzerland) · CHSimon Fraser University · CATRIUMF · CAUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The large, neutral L-type amino acid transporters (LAT1-LAT4) are sodium-independent transporters that are widely distributed throughout the body. LAT expression levels are increased in many types of cancer, and their expression increases as cancers progress, leading to high expression levels in high-grade tumors and metastases. Because of the key role and overexpression of LAT in many types of cancer, radiolabeled LAT substrates are promising candidates for nuclear imaging of malignancies that are not well revealed by conventional radiotracers. The goal of this study was to examine the structure-activity relationships of a series of

Indexed as

Fluorine RadioisotopesPositron-Emission TomographyAmino Acids, Branched-ChainAnimalsBiological TransportCell Line, TumorCell Transformation, NeoplasticHumansMiceRadiochemistryStructure-Activity RelationshipTissue DistributionAmino Acids, Branched-ChainFluorine-18Fluorine Radioisotopes18F radical fluorinationLAT transportstructure–activity relationships

Identifiers

PMID30683769
PMCPMC6604688
OpenAlexW2915048372

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.