Evidence map›Paper›PMID 30683721›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Genetically modified hematopoietic stem/progenitor cells that produce IL-10-secreting regulatory T cells.

Sze-Ling Ng, Ester Leno-Duran, Dibyendu Samanta, Steven C Almo, Jack L Strominger

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Generation of T Cell Receptor Retrogenic Mice.Current protocols in immunology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Sze-Ling NgDepartment of Stem Cell & Regenerative Biology, Harvard University, Cambridge, MA 02138.
Ester Leno-DuranDepartment of Stem Cell & Regenerative Biology, Harvard University, Cambridge, MA 02138.
Dibyendu SamantaAlbert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461.
Steven C AlmoAlbert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461.
Jack L StromingerDepartment of Stem Cell & Regenerative Biology, Harvard University, Cambridge, MA 02138; jlstrom@fas.harvard.edu.
Albert Einstein College of Medicine · USHarvard University · USHarvard Stem Cell Institute · US

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI THOMAS E ROHAN · 1985 to 2026
$111.2M
The NYSGRC: A Large Scale Center for PSI:BiologyU54GM094662 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ALMO, STEVEN C. · 2010 to 2014
$32.6M
Consortia for High-Throughput-Enabled Structural Biology Partnerships (U01)U01GM094665 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SHARPE, ARLENE H. · 2010 to 2014
$5.5M
Genetically modified HSC-HPC for management of aggressive demyelinating diseasesR21AI103701 · NIAID · HARVARD UNIVERSITY · PI STROMINGER, JACK L · 2015 to 2016
$465k
NCI NIH HHS P30 CA013330NIAID NIH HHS R21 AI103701NIGMS NIH HHS U01 GM094665NIGMS NIH HHS U54 GM094662
6 · The paper itself

Abstract

Random amino acid copolymers used in the treatment of multiple sclerosis in man or experimental autoimmune encephalomyelitis (EAE) in mice [poly(Y,E,A,K)

Indexed as

AnimalsDNA, ComplementaryEncephalomyelitis, Autoimmune, ExperimentalFemaleGenetic VectorsHematopoietic Stem CellsImmune ToleranceInterleukin-10InterleukinsMiceMice, TransgenicReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocytes, RegulatoryTumor Necrosis FactorsDNA, ComplementaryIL10 protein, mouseInterleukin-10InterleukinsReceptors, Antigen, T-Cell, gamma-deltaTnfsf18 protein, mouseTumor Necrosis Factorscytokinesimmunosuppressionmultiple sclerosisretrovirus

Identifiers

PMID30683721
PMCPMC6377493
OpenAlexW2914897371

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.