Evidence map›Paper›PMID 30683707›Full record

ReviewJournal of neurology, neurosurgery, and psychiatry2019

Pathophysiological and cognitive mechanisms of fatigue in multiple sclerosis.

Zina-Mary Manjaly, Neil A Harrison, Hugo D Critchley, Cao Tri Do, Gabor Stefanics, Nicole Wenderoth, Andreas Lutterotti, Alfred Müller, Klaas Enno Stephan

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of neurology, neurosurgery, and psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 158 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
158citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06293079 nacompletednot on this mapstarted 2023, after this paper: background citation

The Effect of Hybrid Telerehabilitation-Based Structured Exercise Programs on Gait, Functional Capacity, EMG Muscle Activation and Fatigue in Patients With Multiple Sclerosis

TypeinterventionalSponsorBiruni UniversityRan2023 to 2024Enrolled44ConditionsMultiple SclerosisArmsExercise Program
NCT06699095 narecruitingnot on this mapstarted 2024, after this paper: background citation

"Tele-riabilitazione in Sclerosi Multipla: Continuità Terapeutica Domiciliare Dopo Trattamento Di Neuro-riabilitazione Intensiva, Studio Randomizzato Controllato Con Piattaforma Integrata Per La Riabilitazione Del Disequilibrio"

TypeinterventionalSponsorFondazione I.R.C.C.S. Istituto Neurologico Carlo BestaRan2024 to 2025Enrolled20ConditionsMultiple SclerosisArmsTelerehabilitation
3 · Its place in the literature

Who cites it

158 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  12. Assessment of muscle fatigue in multiple sclerosis patients in electromyographic examinations.European journal of physical and rehabilitation medicine · 2023
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  15. Fatigue and contributing factors in relapsing-remitting multiple sclerosis: a descriptive study based on the comprehensive fatigue assessment battery for multiple sclerosis (CFAB-MS).Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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98 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zina-Mary ManjalyDepartment of Neurology, Schulthess Clinic, Zürich, Switzerland zina-mary.manjaly@kws.ch.ORCID 0000-0002-9217-1688
Neil A HarrisonDepartment of Neuroscience, Brighton and Sussex Medical School, University of Sussex, Brighton, UK.
Hugo D CritchleyDepartment of Neuroscience, Brighton and Sussex Medical School, University of Sussex, Brighton, UK.
Cao Tri DoTranslational Neuromodeling Unit (TNU), Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland.
Gabor StefanicsTranslational Neuromodeling Unit (TNU), Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland.
Nicole WenderothDepartment of Health Sciences and Technology, ETH Zurich, Zürich, Switzerland.
Andreas LutterottiDepartment of Neurology, University Hospital Zurich, Zurich, Switzerland.
Alfred MüllerDepartment of Neurology, Schulthess Clinic, Zürich, Switzerland.
Klaas Enno StephanTranslational Neuromodeling Unit (TNU), Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fatigue is one of the most common symptoms in multiple sclerosis (MS), with a major impact on patients' quality of life. Currently, treatment proceeds by trial and error with limited success, probably due to the presence of multiple different underlying mechanisms. Recent neuroscientific advances offer the potential to develop tools for differentiating these mechanisms in individual patients and ultimately provide a principled basis for treatment selection. However, development of these tools for differential diagnosis will require guidance by pathophysiological and cognitive theories that propose mechanisms which can be assessed in individual patients. This article provides an overview of contemporary pathophysiological theories of fatigue in MS and discusses how the mechanisms they propose may become measurable with emerging technologies and thus lay a foundation for future personalised treatments.

Indexed as

BrainCognitionFatigueHumansMultiple Sclerosisdopaminedyshomeostasisinflammationinteroceptionlesionmetacognitionnetwork

Identifiers

PMID30683707
PMCPMC6581095

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.