Evidence map›Paper›PMID 30683698›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

Gα

Ali Vural, Neel R Nabar, Il-Young Hwang, Silke Sohn, Chung Park, Mikael C I Karlsson, Joe B Blumer, John H Kehrl

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Single-Cell Sequencing Reveals Functional Alterations in Tuberculosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  5. First Potent Macrocyclic AACS pharmacology & translational science · 2023
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. AKT Regulates NLRP3 Inflammasome Activation by Phosphorylating NLRP3 Serine 5.Journal of immunology (Baltimore, Md. : 1950) · 2020
    Article
  12. Article
  13. Hydrogen Sulfide Plays an Important Role by Influencing NLRP3 inflammasome.International journal of biological sciences · 2020
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Ali VuralB-Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0002-1269-6338
Neel R NabarB-Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; neel.nabar@nih.gov jkehrl@niaid.nih.gov.ORCID 0000-0002-9704-3570
Il-Young HwangB-Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Silke SohnDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 77 Stockholm, Sweden; and.ORCID 0000-0002-7051-0933
Chung ParkB-Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0002-7819-5333
Mikael C I KarlssonDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 77 Stockholm, Sweden; and.
Joe B BlumerDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC 29425.ORCID 0000-0002-0020-3815
John H KehrlB-Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; neel.nabar@nih.gov jkehrl@niaid.nih.gov.ORCID 0000-0002-6526-159X
National Institutes of Health · USKarolinska Institutet · SEMedical University of South Carolina · US

Funding

Signal Transduction In B Lymphocytes: Identification Of Key Signaling MoleculesZIAAI000739 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KEHRL, JOHN H · 2009 to 2025
$17.8M
Analysis of the Functional Roles of a Novel G-alpha Nucleotide CycleZIAAI000961 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KEHRL, JOHN H · 2009 to 2018
$4.4M
Intramural NIH HHS ZIA AI000961
6 · The paper itself

Abstract

Macrophages exist as innate immune subsets that exhibit phenotypic heterogeneity and functional plasticity. Their phenotypes are dictated by inputs from the tissue microenvironment. G-protein-coupled receptors are essential in transducing signals from the microenvironment, and heterotrimeric Gα signaling links these receptors to downstream effectors. Several Gα

Indexed as

AnimalsCells, CulturedCytokinesGTP-Binding Protein alpha Subunit, Gi2InflammasomesMacrophagesMiceMice, Inbred C57BLMice, KnockoutPhenotypeSignal TransductionCytokinesGTP-Binding Protein alpha Subunit, Gi2Inflammasomes

Identifiers

PMID30683698
PMCPMC6382563
OpenAlexW2914542340

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.