Evidence map›Paper›PMID 30683671›Full record

ArticleMolecular cancer research : MCR2019

Insight into the Etiology of Undifferentiated Soft Tissue Sarcomas from a Novel Mouse Model.

Jonathan T Fleming, Emily Brignola, Lei Chen, Yan Guo, Shilin Zhao, Quan Wang, Bingshan Li, Hernán Correa, Alexandre N Ermilov, Andrzej A Dlugosz and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cancer research : MCR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jonathan T FlemingDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee.
Emily BrignolaDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee.
Lei ChenDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee.
Yan GuoDepartment of Cancer Biology, Vanderbilt University, Nashville, Tennessee.
Shilin ZhaoDepartment of Cancer Biology, Vanderbilt University, Nashville, Tennessee.
Quan WangDepartment of Molecular Physiology and Biophysics, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee.
Bingshan LiDepartment of Molecular Physiology and Biophysics, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee.
Hernán CorreaDepartment of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, Tennessee.
Alexandre N ErmilovDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan.
Andrzej A DlugoszDepartments of Dermatology and Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan.ORCID 0000-0002-9791-3257
Chin ChiangDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee. chin.chiang@vanderbilt.edu.
Vanderbilt University · USUniversity of Michigan · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
Targeting breast cancer stem cellsR35CA197585 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WICHA, MAX S. · 2016 to 2022
$6.4M
MOLECULAR BASIS OF EPITHELIAL SKIN CANCERR01CA087837 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DLUGOSZ, ANDRZEJ A. · 2000 to 2014
$4.9M
Shh signaling in cerebellar function and diseaseR01NS097898 · NINDS · VANDERBILT UNIVERSITY · PI CHIANG, CHIN · 2016 to 2019
$1.6M
LSM880-Airyscan Confocal Microscope for Large Shared ResourceS10OD021630 · OD · VANDERBILT UNIVERSITY · PI WELLS, K. SAM · 2016 to 2016
$560k
NCI NIH HHS P30 CA046592NCI NIH HHS P30 CA068485NCI NIH HHS R01 CA087837NCI NIH HHS R35 CA197585NIH HHS S10 OD021630NINDS NIH HHS R01 NS097898
6 · The paper itself

Abstract

Aberrant activation of the Hedgehog signaling pathway has been linked to the formation of numerous cancer types, including the myogenic soft tissue sarcoma, embryonal rhabdomyosarcoma (eRMS). Here, we report

Indexed as

AnimalsGene Expression Regulation, NeoplasticHedgehog ProteinsHomeobox Protein Nkx-2.2Homeodomain ProteinsHumansMiceNeoplasm TransplantationNerve Tissue ProteinsNuclear ProteinsSarcoma, EwingSignal TransductionTranscription FactorsZebrafish ProteinsZinc Finger Protein Gli3GLI3 protein, humanHedgehog ProteinsHomeobox Protein Nkx-2.2Homeodomain ProteinsNerve Tissue Proteinsnkx2.2b protein, zebrafishNKX2-2 protein, humanNkx2-2 protein, mouseNuclear ProteinsTranscription FactorsZebrafish ProteinsZinc Finger Protein Gli3

Identifiers

PMID30683671
PMCPMC6497566
OpenAlexW2913721799

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.