Evidence map›Paper›PMID 30683666›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2019

A Polymeric Nanogel-Based Treatment Regimen for Enhanced Efficacy and Sequential Administration of Synergistic Drug Combination in Pancreatic Cancer.

Kruti S Soni, Divya Thomas, Thomas Caffrey, Kamiya Mehla, Fan Lei, Kelly A O'Connell, Satish Sagar, Subodh M Lele, Michael A Hollingsworth, Prakash Radhakrishnan and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
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  4. Article
  5. Glycosylation and its research progress in endometrial cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Nanoscale platform for delivery of active IRINOX to combat pancreatic cancer.Journal of controlled release : official journal of the Controlled Release Society · 2021
    Article
  11. Altered glycosylation in cancer: A promising target for biomarkers and therapeutics.Biochimica et biophysica acta. Reviews on cancer · 2021
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Kruti S SoniDepartment of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine, College of Pharmacy (K.S.S., F.L., T.K.B.), Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center (D.T., T.C., K.M., K.A.O., S.S., M.A.H., P.R.), and Department of Pathology and Microbiology (S.M.L.), University of Nebraska Medical Center, Omaha, Nebraska.
Divya ThomasDepartment of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine, College of Pharmacy (K.S.S., F.L., T.K.B.), Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center (D.T., T.C., K.M., K.A.O., S.S., M.A.H., P.R.), and Department of Pathology and Microbiology (S.M.L.), University of Nebraska Medical Center, Omaha, Nebraska.
Thomas CaffreyDepartment of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine, College of Pharmacy (K.S.S., F.L., T.K.B.), Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center (D.T., T.C., K.M., K.A.O., S.S., M.A.H., P.R.), and Department of Pathology and Microbiology (S.M.L.), University of Nebraska Medical Center, Omaha, Nebraska.
Kamiya MehlaDepartment of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine, College of Pharmacy (K.S.S., F.L., T.K.B.), Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center (D.T., T.C., K.M., K.A.O., S.S., M.A.H., P.R.), and Department of Pathology and Microbiology (S.M.L.), University of Nebraska Medical Center, Omaha, Nebraska.
Fan LeiDepartment of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine, College of Pharmacy (K.S.S., F.L., T.K.B.), Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center (D.T., T.C., K.M., K.A.O., S.S., M.A.H., P.R.), and Department of Pathology and Microbiology (S.M.L.), University of Nebraska Medical Center, Omaha, Nebraska.
Kelly A O'ConnellDepartment of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine, College of Pharmacy (K.S.S., F.L., T.K.B.), Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center (D.T., T.C., K.M., K.A.O., S.S., M.A.H., P.R.), and Department of Pathology and Microbiology (S.M.L.), University of Nebraska Medical Center, Omaha, Nebraska.
Satish SagarDepartment of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine, College of Pharmacy (K.S.S., F.L., T.K.B.), Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center (D.T., T.C., K.M., K.A.O., S.S., M.A.H., P.R.), and Department of Pathology and Microbiology (S.M.L.), University of Nebraska Medical Center, Omaha, Nebraska.
Subodh M LeleDepartment of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine, College of Pharmacy (K.S.S., F.L., T.K.B.), Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center (D.T., T.C., K.M., K.A.O., S.S., M.A.H., P.R.), and Department of Pathology and Microbiology (S.M.L.), University of Nebraska Medical Center, Omaha, Nebraska.
Michael A HollingsworthDepartment of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine, College of Pharmacy (K.S.S., F.L., T.K.B.), Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center (D.T., T.C., K.M., K.A.O., S.S., M.A.H., P.R.), and Department of Pathology and Microbiology (S.M.L.), University of Nebraska Medical Center, Omaha, Nebraska.
Prakash RadhakrishnanDepartment of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine, College of Pharmacy (K.S.S., F.L., T.K.B.), Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center (D.T., T.C., K.M., K.A.O., S.S., M.A.H., P.R.), and Department of Pathology and Microbiology (S.M.L.), University of Nebraska Medical Center, Omaha, Nebraska pradhakr@unmc.edu.
Tatiana K BronichDepartment of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine, College of Pharmacy (K.S.S., F.L., T.K.B.), Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center (D.T., T.C., K.M., K.A.O., S.S., M.A.H., P.R.), and Department of Pathology and Microbiology (S.M.L.), University of Nebraska Medical Center, Omaha, Nebraska tbronich@unmc.edu.
University of Nebraska Medical Center · US

Funding

Project 9 - Renal Drug Targeting for the Treatment of Lupus NephritisP20GM103480 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BRONICH, TATIANA K · 2012 to 2017
$13.3M
Nebraska Center for Nanomedicine- Pilot ProjectsP30GM127200 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI OUPICKY, DAVID · 2018 to 2022
$5.7M
Targeted Core Shell Nanogels for Triple Negative Breast CancerU01CA198910 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BRONICH, TATIANA K, KABANOV, ALEXANDER V · 2015 to 2019
$2.8M
MUC16 in Pancreatic Cancer Progression and MetastasisR01CA208108 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI RADHAKRISHNAN, PRAKASH · 2017 to 2021
$1.7M
NCI NIH HHS R01 CA208108NCI NIH HHS U01 CA198910NIGMS NIH HHS P20 GM103480NIGMS NIH HHS P30 GM127200
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers. A combination of cisplatin (CDDP) and gemcitabine (Gem) treatment has shown favorable clinical results for metastatic disease; both are limited by toxicities and nontargeted delivery. More than 80% of PDAC aberrantly expresses the sialyl Tn (STn) antigen due to the loss of function of the core 1

Indexed as

AnimalsAntimetabolites, AntineoplasticAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsCarcinoma, Pancreatic DuctalCell Line, TumorCisplatinDeoxycytidineDrug SynergismGelsGemcitabineHumansMiceMice, NudeNanostructuresPancreatic NeoplasmsAntimetabolites, AntineoplasticAntineoplastic AgentsCisplatinDeoxycytidineGelsGemcitabinePlatinumPolymers

Identifiers

PMID30683666
PMCPMC6807295
OpenAlexW2911469937

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.