ArticleNeuron2019
Structured Odorant Response Patterns across a Complete Olfactory Receptor Neuron Population.
Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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50 citing papers in PubMed.
- Titrating the Smell of Fear: Initial Evidence for Dose-Invariant Behavioral, Physiological, and Neural Responses.Psychological science · 2021Trial
- Selective lifelong suppression of an odor processing channel in response to critical period experience.eLife · 2026Article
- The larvalScience advances · 2026Article
- Undoing of firing rate adaptation enables invariant population codes.Science advances · 2026Article
- Convergent motifs of early olfactory processing are recapitulated by layer-wise efficient coding.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The larvalbioRxiv : the preprint server for biology · 2026Article
- Investigating the Structural Basis of Diacetyl Recognition by the G-Protein-Coupled Receptor ODR-10 inThe journal of physical chemistry. B · 2025Article
- Integrative functional optical imaging approaches: Optics, microfluidics, and machine learning for neuroscience in organoids and small-animal models.Biophysical journal · 2025Review
- Convergent motifs of early olfactory processing are recapitulated by layer-wise efficient coding.bioRxiv : the preprint server for biology · 2025Article
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- Hybrid neural networks in the mushroom body drive olfactory preference inScience advances · 2025Article
- Dynamics of two distinct memory interactions during water seeking inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Nonlinear high-activity neuronal excitation enhances odor discrimination.Current biology : CB · 2025Article
- Olfactory Receptor Responses to Pure Odorants in Drosophila melanogaster.The European journal of neuroscience · 2025Article
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- Glia control experience-dependent plasticity in an olfactory critical period.bioRxiv : the preprint server for biology · 2024Article
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- Stimulus duration encoding occurs early in the moth olfactory pathway.Communications biology · 2024Article
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8 authors.
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Abstract
Odor perception allows animals to distinguish odors, recognize the same odor across concentrations, and determine concentration changes. How the activity patterns of primary olfactory receptor neurons (ORNs), at the individual and population levels, facilitate distinguishing these functions remains poorly understood. Here, we interrogate the complete ORN population of the Drosophila larva across a broadly sampled panel of odorants at varying concentrations. We find that the activity of each ORN scales with the concentration of any odorant via a fixed dose-response function with a variable sensitivity. Sensitivities across odorants and ORNs follow a power-law distribution. Much of receptor sensitivity to odorants is accounted for by a single geometrical property of molecular structure. Similarity in the shape of temporal response filters across odorants and ORNs extend these relationships to fluctuating environments. These results uncover shared individual- and population-level patterns that together lend structure to support odor perceptions.
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