Evidence map›Paper›PMID 30683457›Full record

Trial reportInternational journal of cardiology2019

Effect of short-term colchicine treatment on endothelial function in patients with coronary artery disease.

Masato Kajikawa, Yukihito Higashi, Hirofumi Tomiyama, Tatsuya Maruhashi, Satoshi Kurisu, Yasuki Kihara, Akiko Mutoh, Shin-Ichiro Ueda

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in International journal of cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06286423 (Colchicine in Acutely Decompensated Heart Failure With Reduced Ejection Fraction), which is not on this map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06286423 phase4recruitingnot on this mapstarted 2024, after this paper: background citation

Colchicine in Acutely Decompensated Heart Failure With Reduced Ejection Fraction: a Pilot Study

TypeinterventionalSponsorUniversity of VirginiaRan2024 to 2028Enrolled30ConditionsHeart Failure, Decompensated Heart Failure, Heart Failure With Reduced Ejection FractionArmsColchicine 0.6 mg, Control/Placebo group
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Pooled it
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  11. Article
  12. Review
  13. Colchicine for Coronary Artery Disease: A Review.Frontiers in cardiovascular medicine · 2022
    Review
  14. Review
  15. Emerging Anti-Atherosclerotic Therapies.International journal of molecular sciences · 2021
    Review
  16. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Masato KajikawaDivision of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan.
Yukihito HigashiDivision of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan; Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan. Electronic address: yhigashi@hiroshima-u.ac.jp.
Hirofumi TomiyamaDepartment of Cardiology, Tokyo Medical University, Tokyo, Japan.
Tatsuya MaruhashiDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Satoshi KurisuDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Yasuki KiharaDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Akiko MutohDepartment of Clinical Pharmacology and Therapeutics, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Shin-Ichiro UedaDepartment of Clinical Pharmacology and Therapeutics, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan. Electronic address: blessyou@med.u-ryukyu.ac.jp.
Hiroshima University · JPUniversity of the Ryukyus · JPHiroshima University Hospital · JPTokyo Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInflammation is associated with endothelial dysfunction and plays an important role in the pathogenesis and development of cardiovascular diseases. It has been shown that colchicine, an anti-inflammatory drug, improves the cardiovascular outcome in patients with cardiovascular disease. The purpose of this study was to evaluate the short-term effect of low-dose colchicine on endothelial function in patients with coronary artery disease (CAD).

methodsThis was a double-blind, randomized, placebo-controlled, crossover-within-subject clinical trial. A total of 28 patients with CAD received low-dose colchicine (0.5 mg/day) or a placebo for 7 days with a washout period of at least 14 days. Flow-mediated vasodilation (FMD) and serum concentrations of high-sensitivity C-reactive protein (hs-CRP) were measured after the 7-day treatment with colchicine or the placebo.

resultsThe serum concentration of hs-CRP was significantly decreased after administration of colchicine compared with that after administration of the placebo [median (interquartile range): 0.04 (0.02-0.08) mg/dL vs. 0.07 (0.04-0.11) mg/dL, P = 0.003], while there was no significant difference in FMD between the treatments [median (interquartile range): 3.1% (1.5-5.3%) vs. 3.3% (1.9-5.2%), P = 0.384]. Colchicine, however, significantly improved FMD in coronary artery disease patients with white blood cell (WBC) counts of ≥7500 WBC/mm

conclusionsAdministration of low-dose colchicine did not improve endothelial function in patients with CAD, but exploratory analysis suggested that endothelial function is significantly improved in patients with leukocyte activation.

Indexed as

AgedColchicineCoronary Artery DiseaseCross-Over StudiesDouble-Blind MethodDrug Administration ScheduleEndothelium, VascularFemaleGout SuppressantsHumansMaleMiddle AgedTreatment OutcomeUltrasonography, InterventionalColchicineGout SuppressantsAtherosclerosisCardiovascular diseaseColchicineEndothelial function

Identifiers

PMID30683457
OpenAlexW2908842777

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.