ArticleNutrition research (New York, N.Y.)2019
Maternal undernutrition during pregnancy alters the epigenetic landscape and the expression of endothelial function genes in male progeny.
Article in Nutrition research (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Investigating Aging and DNA Methylation: A Path to Improving Health Span?The Yale journal of biology and medicine · 2025Review
- A maternal hypoxia mouse model to study the effect of late gestational hypoxia on offspring lung outcomes.Frontiers in physiology · 2025Article
- Prenatal LPS leads to increases in RAS expression within the PVN and overactivation of sympathetic outflow in offspring rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Serum anti-mullerian hormone, sex hormone, and nutrient levels in reproductive age women with celiac disease.Journal of assisted reproduction and genetics · 2024Article
- Low nephron endowment increases susceptibility to renal stress and chronic kidney disease.JCI insight · 2023Article
- Accounting for diverse evolutionary forces reveals mosaic patterns of selection on human preterm birth loci.Nature communications · 2020Article
- Nutrition and its role in epigenetic inheritance of obesity and diabetes across generations.Mammalian genome : official journal of the International Mammalian Genome Society · 2020Review
- Schizophrenia Mortality: Barriers to Progress.The Psychiatric quarterly · 2019Review
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Authors and funding
3 authors at 2 institutions in 1 country.
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Abstract
Recent studies point to the important role of in utero malnutrition in gene programming and in the development of vascular diseases. We hypothesize that maternal undernutrition affects vascular function in the offspring by promoting epigenetic changes that drive the differential expression of genes involved in endothelial function. To test this, we exposed mice to nutrient deprivation in utero and analyzed its effect on global DNA methylation and expression of endothelium-specific genes in the pulmonary endothelium of the adult progeny. Mice were kept either on ad libitum (AL) or energy-restricted (ER) diet during the second and third trimesters of gestation. Mice in the ER group received 65% of energy compared to mice in the AL diet group. Pulmonary endothelial cells were isolated from 6-week-old male offspring mice (AL-F1 and ER-F1). The expression of genes in the pulmonary endothelium was analyzed using quantitative reverse-transcription polymerase chain reaction array and confirmed by qRT-PCR. Several genes including fibronectin 1 and plasminogen activator inhibitor 1 were upregulated in the endothelium of male ER-F1 mice, whereas the expression of genes involved in regulation of histone acetylation was significantly attenuated. At the same time, the global DNA methylation did not change in pulmonary endothelial cells of ER-F1 mice compared to AL-F1 mice. Overall, we found that maternal undernutrition during pregnancy affects the expression of genes involved in regulation of endothelial cell function in the pulmonary vasculature of male progeny, which could potentially promote pulmonary vascular remodeling.
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