Trial reportBMC psychiatry2019
Hyperactivity/restlessness is associated with increased functional connectivity in adults with ADHD: a dimensional analysis of resting state fMRI.
Trial report in BMC psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- A resting-state functional magnetic resonance imaging meta-analysis of differences in brain activity between children and adolescents with attention-deficit/hyperactivity disorder using activation likelihood estimation.European child & adolescent psychiatry · 2026Pooled it
- The impact of physical activity on inhibitory control of adult ADHD: a systematic review and meta-analysis.Journal of global health · 2025Pooled it
- Brain gray matter structures associated with trait impulsivity: A systematic review and voxel-based meta-analysis.Human brain mapping · 2021Pooled it
- Individualised Structural and Functional Frontostriatal Connectivity Mapping in Adult ADHD.Human brain mapping · 2026Article
- Robust Multi-Site ADHD Classification via GraphSAGE-Based Functional Connectivity Modeling from rs-fMRI.Bioengineering (Basel, Switzerland) · 2026Article
- Cholinergic network disruptions on cognitive function across the spectrum of cognitive impairment in Parkinson's disease.Journal of neurology · 2025Article
- Associations of neighborhood threat and deprivation with psychopathology: Uncovering neural mechanisms.Development and psychopathology · 2025Article
- Stimulant medication and symptom interrelations in children, adolescents and adults with attention-deficit/hyperactivity disorder.European child & adolescent psychiatry · 2025Article
- Investigating resting-state functional connectivity changes within procedural memory network across neuropsychiatric disorders using fMRI.BMC medical imaging · 2025Article
- Real-world goal-directed behavior reveals aberrant functional brain connectivity in children with ADHD.PloS one · 2025Article
- Alterations of the resting-state brain network connectivity and gray matter volume in patients with fibromyalgia in comparison to ankylosing spondylitis.Scientific reports · 2024Article
- Controllability in attention deficit hyperactivity disorder brains.Cognitive neurodynamics · 2024Article
- Interference of default mode on attention networks in adults with attention-deficit/hyperactivity disorder and its association with genetic variants and treatment outcomes.CNS neuroscience & therapeutics · 2024Article
- Different brain functional network abnormalities between attention-deficit/hyperactivity disorder youth with and without familial risk for bipolar disorder.European child & adolescent psychiatry · 2024Article
- Increased Serum Terminal Complements Complex Levels in Attention Deficit Hyperactivity Disorder Children.Iranian journal of medical sciences · 2024Article
- Delineating Transdiagnostic Subtypes in Neurodevelopmental Disorders via Contrastive Graph Machine Learning of Brain Connectivity Patterns.bioRxiv : the preprint server for biology · 2024Article
- A three-dimensional model of neural activity and phenomenal-behavioral patterns.Molecular psychiatry · 2024Review
- Adult Attention-Deficit/Hyperactivity Disorder: a Narrative Review of Biological Mechanisms, Treatments, and Outcomes.Current neurology and neuroscience reports · 2023Review
- Functional and structural brain network development in children with attention deficit hyperactivity disorder.Human brain mapping · 2023Article
- Identifying Replicable Subgroups in Neurodevelopmental Conditions Using Resting-State Functional Magnetic Resonance Imaging Data.JAMA network open · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdult attention-deficit/hyperactivity disorder (ADHD) is a serious and frequent psychiatric disorder of multifactorial pathogenesis. Several lines of evidence support the idea that ADHD is, in its core, a disorder of dysfunctional brain connectivity within and between several neurofunctional networks. The primary aim of this study was to investigate associations between the functional connectivity within resting state brain networks and the individual severity of core ADHD symptoms (inattention, hyperactivity, and impulsivity).
methodsResting state functional magnetic resonance imaging (rs-fMRI) data of 38 methylphenidate-naïve adults with childhood-onset ADHD (20 women, mean age 40.5 years) were analyzed using independent component analysis (FSL's MELODIC) and FSL's dual regression technique. For motion correction, standard volume-realignment followed by independent component analysis-based automatic removal of motion artifacts (FSL's ICA-AROMA) were employed. To identify well-established brain networks, the independent components found in the ADHD group were correlated with brain networks previously found in healthy participants (Smith et al. PNAS 2009;106:13040-5). To investigate associations between functional connectivity and individual symptom severity, sex, and age, linear regressions were performed.
resultsDecomposition of resting state brain activity of adults with ADHD resulted in similar resting state networks as previously described for healthy adults. No significant differences in functional connectivity were seen between women and men. Advanced age was associated with decreased functional connectivity in parts of the bilateral cingulate and paracingulate cortex within the executive control network. More severe hyperactivity was associated with increased functional connectivity in the left putamen, right caudate nucleus, right central operculum and a portion of the right postcentral gyrus within the auditory/sensorimotor network.
conclusionsThe present study supports and extends our knowledge on the involvement of the striatum in the pathophysiology of ADHD, in particular, in the pathogenesis of hyperactivity. Our results emphasize the usefulness of dimensional analyses in the study of ADHD, a highly heterogeneous disorder.
trial registrationISRCTN12722296 ( https://doi.org/10.1186/ISRCTN12722296 ).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.