ArticleBrain, behavior, and immunity2019
Understanding associations of early-life adversities with mid-life inflammatory profiles: Evidence from the UK and USA.
Article in Brain, behavior, and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association of child maltreatment and systemic inflammation in adulthood: A systematic review.PloS one · 2021Pooled it
- Maternal adversity and peripheral proinflammatory cytokine concentrations in pregnancy.Brain, behavior, & immunity - health · 2026Article
- Associations between women's childhood maltreatment and thyroid function before and during pregnancy.Scientific reports · 2026Article
- The Effects of Childhood Abuse on Emerging Adulthood Inflammation: Investigating Protective Characteristics.Child maltreatment · 2025Article
- Exploring Pathways from Childhood Adversity to Substance Use in Young Adults.International journal of environmental research and public health · 2025Article
- Characterization of inflammatory and neurofunctional markers in the context of early life stress among a clinical sample of people maintained on buprenorphine for opioid use disorder.Brain, behavior, & immunity - health · 2025Article
- Adverse childhood experiences, inflammation, and depression: evidence of sex- and stressor specific effects in a nationally representative longitudinal sample of U.S. adolescents.Psychological medicine · 2025Article
- Estimating the associations between women's maltreatment in childhood and inflammatory biomarker levels prior to and during pregnancy.PloS one · 2025Article
- Sex-specific associations between childhood trauma and adult systemic inflammation in daily life.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2024Article
- Human immune and metabolic biomarker levels, and stress-biomarker associations, differ by season: Implications for biomedical health research.Brain, behavior, & immunity - health · 2024Article
- Lingering Effects of Early Institutional Rearing and Cytomegalovirus Infection on the Natural Killer Cell Repertoire of Adopted Adolescents.Biomolecules · 2024Article
- Relationships between childhood adversity and inflammatory biomarkers in adulthood: A cross-sectional analysis of a middle-to older-aged population.SSM - population health · 2024Article
- Early life adversities and lifelong health outcomes: A review of the literature on large, social, long-lived nonhuman mammals.Neuroscience and biobehavioral reviews · 2023Review
- Systemic Inflammation Contributes to the Association Between Childhood Socioeconomic Disadvantage and Midlife Cardiometabolic Risk.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2023Article
- Article
- Specific Associations Between Type of Childhood Abuse and Elevated C-Reactive Protein in Young Adult Psychiatric Rehabilitation Participants.The international journal of neuropsychopharmacology · 2022Article
- Measuring early life adversity: A dimensional approach.Development and psychopathology · 2022Review
- Addressing the biological embedding of early life adversities (ELA) among adults through mindfulness: Proposed mechanisms and review of converging evidence.Neuroscience and biobehavioral reviews · 2022Review
- Sex-specific behavioral outcomes of early-life adversity and emerging microglia-dependent mechanisms.Frontiers in behavioral neuroscience · 2022Article
- Promoting brain health through physical activity among adults exposed to early life adversity: Potential mechanisms and theoretical framework.Neuroscience and biobehavioral reviews · 2021Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectivesIn two cohorts, we aimed to establish associations between early-life adversities and adult inflammation, and whether adult (a) adiposity or (b) socioeconomic disadvantage are key intermediaries.
methodsIn both cohorts (N = 7661, 1958 British birth cohort; N = 1255, MIDUS), information was used on adult inflammatory markers (C-reactive protein (CRP), fibrinogen and (MIDUS only) interleukin-6 (IL-6)), adiposity and socioeconomic disadvantage, and early-life adversities (neglect, emotional neglect, physical, psychological, sexual abuse and childhood disadvantage).
resultsEarly-life adversities varied from 1.6% (sexual abuse, 1958 cohort) to 14.3% (socioeconomic disadvantage, MIDUS). Across the two cohorts, associations were consistent for physical abuse, e.g. 16.3%(3.01,29.7) and 17.0%(-16.4,50.3) higher CRP in the 1958 cohort and MIDUS respectively. Associations attenuated after accounting for adult adiposity, e.g. physical abuse (1958 cohort) and sexual abuse (MIDUS, non-white participants) associations were abolished. Some associations attenuated after adjustment for adult socioeconomic disadvantage; e.g. 1958 cohort neglect-CRP associations reduced from 23.2%(13.7,32.6) to 17.7%(8.18,27.2). Across the cohorts, no associations were found for psychological abuse or emotional neglect; associations for childhood socioeconomic disadvantage were inconsistent.
conclusionsSpecific early-life adversities are associated with adult inflammation; adiposity is a likely intermediary factor. Weight reduction and obesity prevention may offset pro-inflammatory related adult disease among those who experienced early-life adversities.
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Registered trials
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