ArticlePloS one2019
Lowering barometric pressure induces neuronal activation in the superior vestibular nucleus in mice.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- A Global Perspective on Migraine Attack Triggers: Understanding Differences Across Lifestyles, Religions, and Regions.Current pain and headache reports · 2026Review
- Meteorological factors and primary care consultation patterns in rheumatoid arthritis and axial spondyloarthritis: a 14-year population-based time-series study.Clinical rheumatology · 2026Article
- Climatic determinants of rheumatic and autoimmune musculoskeletal pain: a fourteen-year primary care time-series study.Scientific reports · 2026Article
- The impact of climatic factors on headache patterns: a 14-year time series analysis of cluster and tension-type headaches in primary care.Journal of oral & facial pain and headache · 2026Article
- Weather, air pollution, and migraine: A case-time series analysis examining environmental exposures and transient health outcomes recorded via smartphone application.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Impact of climatic factors on trigeminal neuralgia and facial neuropathy in primary care during a fourteen-year time-series study.Scientific reports · 2026Article
- Fixed-wing air transport of patients with spinal pathologies: a scoping review of current evidence and future research priorities.Acta neurochirurgica · 2026Article
- Body, mind, and weather: mechanisms of interaction - a narrative review.Postepy psychiatrii neurologii · 2026Review
- Chinook winds and migraine attack onset in children and adolescents: A prospective longitudinal clinical cohort study.Headache · 2026Article
- The inner ear is a barometric pressure sensor-change in barometric pressure induces vestibular ganglion cell activation in mice.Scientific reports · 2025Article
- Impact of barometric pressure on blood pressure during dialysis: Introducing intradialytic time-averaged cumulative systolic blood pressure (TACsBP-inD) as a new metric.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2025Article
- Pain in the Forecast: Investigating Weather Sensitivity Before and After Total Knee Arthroplasty.Life (Basel, Switzerland) · 2025Article
- Big Five personality traits, BIS/BAS dimensions and meteoropathy: a mediation model.Current issues in personality psychology · 2025Article
- The effects of lowering barometric pressure on pain behavior and the stress hormone in mice with neuropathic pain.PloS one · 2025Article
- Sex-related differences regarding headache triggered by low barometric pressure in Japan.BMC research notes · 2024Article
- Mapping of afferent and efferent connections of phenylethanolamine N-methyltransferase-expressing neurons in the nucleus tractus solitarii.CNS neuroscience & therapeutics · 2024Article
- Whether Weather Matters with Migraine.Current pain and headache reports · 2024Review
- Meteoropathy: a review on the current state of knowledge.Journal of medicine and life · 2023Review
- Tympanostomy tube placement for pressure-sensitive vertigo.Laryngoscope investigative otolaryngology · 2022Article
- Weather sensitivity associated with quality of life in patients with fibromyalgia.BMC rheumatology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Weather changes accompanied by decreases in barometric pressure are suggested to trigger meteoropathy, i.e., weather-related pain. We previously reported that neuropathic pain-related behavior in rats is aggravated by lowering barometric pressure, and that this effect is abolished by inner ear lesions. These results suggest that mechanisms that increase vestibular neuronal activity may parallel those that contribute to meteoropathy generation. However, it remains unknown whether changes in barometric pressure activate vestibular neuronal activity. To address this issue, we used expression of c-Fos protein as a marker for neural activation. Male and female mice were placed in a climatic chamber, and the barometric pressure was lowered by 40 hPa, from 1013 hPa, for 50 min (LP stimulation). The total number of c-Fos-positive cells in the vestibular nuclei was counted bilaterally after LP stimulation. We also video-recorded mouse behaviors and calculated the total activity score during the LP stimulation. LP stimulation resulted in significant c-Fos expression in the superior vestibular nucleus (SuVe) of male and female mice. There was no effect of LP stimulation on the total activity score. These data show that distinct neurons in the SuVe respond to LP stimulation. Similar mechanisms may contribute to the generation of meteoropathy in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.