ArticlePloS one2019
Abnormal cerebellar connectivity and plasticity in isolated cervical dystonia.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07014384 (A Randomized, Sham-controlled Study of Cerebellar Transcranial Direct Current Stimulation), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized, Sham-controlled Study of Cerebellar Transcranial Direct Current Stimulation (tDCS) and Its Effects on the Neurophysiological Properties of the Sensorimotor Network and Motor Symptom Severity in Patients With Isolated Cervical Dystonia (CD)
Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Inhibitory Circuits of the Sensorimotor Network are Not Modulated By Cerebellar Transcranial Direct Current Stimulation in Isolated Cervical Dystonia.Cerebellum (London, England) · 2026Trial
- Versatility of Transcranial Magnetic Stimulation: A Review of Diagnostic and Therapeutic Applications.Brain sciences · 2026Review
- GABAergic and glutamatergic mechanisms of cortical excitability shape motor resonance during action observation as measured by transcranial magnetic stimulation.Frontiers in human neuroscience · 2026Article
- Generalized dystonia unraveled: Molecular mechanisms, diagnostic strategies, and treatment paradigms.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- Structure-function association of the cerebellar motor network is altered in isolated cervical dystonia.Journal of neurology · 2025Article
- Atrophy of cerebellar lobule VI and primary motor cortex in cervical dystonia - a region of interest-based study.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Brain network pathophysiology in dystonia.Dystonia (Lausanne, Switzerland) · 2025Article
- Evaluation of non-motor symptoms in cervical dystonia, hemifacial spasm, and blepharospasm patients and their correlation with motor symptoms.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Observational
- Utilising TMS-EEG to Assess the Response to Cerebellar-Brain Inhibition.Cerebellum (London, England) · 2023Article
- Striatal Subregion-selective Dysregulated Dopamine Receptor-mediated Intracellular Signaling in a Model of DOPA-responsive Dystonia.Neuroscience · 2023Article
- Exploring clinical outcomes in patients with idiopathic/inherited isolated generalized dystonia and stimulation of the subthalamic region.Arquivos de neuro-psiquiatria · 2023Article
- Applications of Transcranial Magnetic Stimulation for Understanding and Treating Dystonia.Advances in neurobiology · 2023Review
- Functional abnormalities in the cerebello-thalamic pathways in a mouse model of DYT25 dystonia.eLife · 2022Article
- Effects of non-invasive brain stimulation in dystonia: a systematic review and meta-analysis.Therapeutic advances in neurological disorders · 2022Article
- Motor learning deficits in cervical dystonia point to defective basal ganglia circuitry.Scientific reports · 2021Article
- Contemporary functional neuroanatomy and pathophysiology of dystonia.Journal of neural transmission (Vienna, Austria : 1996) · 2021Review
- The Pathophysiology of Dystonic Tremors and Comparison With Essential Tremor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Reduced Interhemispheric Coherence after Cerebellar Vermis Output Perturbation.Brain sciences · 2020Article
- Cerebellar-Motor Cortex Connectivity: One or Two Different Networks?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Focal Leg Dystonia Associated with Cerebellar Infarction and Application of Low-Frequency Cerebellar Transcranial Magnetic Stimulation: Evidence of Topographically Specific Cerebellar Contribution to Dystonia Development.Cerebellum (London, England) · 2019Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is increasing evidence that supports the role of the cerebellum in the pathophysiology of dystonia. We used transcranial magnetic stimulation to test the hypothesis that patients with cervical dystonia may have a disrupted cerebellar cortical connectivity at rest, and that cerebellar plasticity is altered too. We enrolled 12 patients with isolated cervical dystonia and 13 controls. A paired-pulse transcranial magnetic stimulation protocol was applied over the right cerebellum and the left primary motor area. Changes in the amplitude of motor evoked potentials were analysed. Continuous and intermittent Theta Burst Stimulation over the cerebellum was also applied. The effects of these repetitive protocols on cortical excitability, on intra-cortical circuits and on cerebellar cortical inhibition were analysed. In healthy subjects, but not in dystonic patients, a conditioning stimulus over the cerebellum was able to inhibit the amplitude of the motor evoked potentials from primary motor cortex. In healthy subjects continuous and intermittent cerebellar Theta Burst Stimulation were able to decrease and increase respectively motor cortex excitability. Continuous Theta Burst Stimulation was able to abolish the cerebellar cortical inhibition observed in basal condition. These effects were not observed in patients with cervical dystonia. Cerebellar cortical connectivity and cerebellar plasticity is altered at rest in patients with cervical dystonia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.