Evidence map›Paper›PMID 30682138›Full record

Observational studyPloS one2019

Outcomes and challenges of a kidney transplant programme at Groote Schuur Hospital, Cape Town: A South African perspective.

Bianca Davidson, Tinus Du Toit, Erika S W Jones, Zunaid Barday, Kathryn Manning, Fiona Mc Curdie, Dave Thomson, Brian L Rayner, Elmi Muller, Nicola Wearne

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Bianca DavidsonDepartment of Nephrology and Hypertension, Groote Schuur Hospital, University of Cape Town, Western Cape, South Africa.ORCID 0000-0002-6974-8581
Tinus Du ToitDepartment of Surgery, University of Cape Town, Western Cape, South Africa.
Erika S W JonesDepartment of Nephrology and Hypertension, Groote Schuur Hospital, University of Cape Town, Western Cape, South Africa.
Zunaid BardayDepartment of Nephrology and Hypertension, Groote Schuur Hospital, University of Cape Town, Western Cape, South Africa.
Kathryn ManningDepartment of Surgery, University of Cape Town, Western Cape, South Africa.
Fiona Mc CurdieDepartment of Nephrology and Hypertension, Groote Schuur Hospital, University of Cape Town, Western Cape, South Africa.
Dave ThomsonDepartment of Surgery, University of Cape Town, Western Cape, South Africa.
Brian L RaynerDepartment of Nephrology and Hypertension, Groote Schuur Hospital, University of Cape Town, Western Cape, South Africa.
Elmi MullerDepartment of Surgery, University of Cape Town, Western Cape, South Africa.
Nicola WearneDepartment of Nephrology and Hypertension, Groote Schuur Hospital, University of Cape Town, Western Cape, South Africa.
University of Cape Town · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAccess to dialysis and transplantation in the developing world remains limited. Therefore, optimising renal allograft survival is essential. This study aimed to evaluate clinical outcomes and identify poor prognostic factors in the renal transplant programme at Groote Schuur Hospital [GSH], Cape Town.     .

methodData were collected on all patients who underwent a kidney transplant at GSH from 1st July 2010 to the 30 June 2015. Analyses were performed to assess baseline characteristics, graft and patient survival, as well as predictors of poor outcome.    .

results198 patients were transplanted. The mean age was 38 +/- 10.5 years, 127 (64.1%) were male, and 86 (43.4%) were of African ethnicity. Deceased donor organs were used for 130 (66.7%) patients and living donors for 65 (33.3%). There were > 5 HLA mismatches in 58.9% of transplants. Sepsis was the commonest cause of death and delayed graft function [DGF] occurred in 41 (21.4%) recipients. Patient survival was 90.4% at 1 year and 83.1% at 5 years. Graft survival was 89.4% at 1 year and 80.0% at 5 years. DGF (HR 2.83 (1.12-7.19), p value = 0.028) and recipient age > 40 years (HR 3.12 (1.26-7.77), p value = 0.014) were predictors of death.

conclusionDespite the high infectious burden, stratified immunosuppression and limited tissue typing this study reports encouraging results from a resource constrained transplant programme in South Africa. Renal transplantation is critical to improve access to treatment of end stage kidney disease where access to dialysis is limited.

Indexed as

Delayed Graft FunctionGraft SurvivalKidney TransplantationLiving DonorsRenal DialysisAdultFemaleHumansMaleMiddle AgedSouth AfricaTransplantation, Homologous

Identifiers

PMID30682138
PMCPMC6347365
OpenAlexW2914320945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.