Observational studyPloS one2019
Trauma induced acute kidney injury.
Observational study in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed.
- Incidence and outcomes of stage 3 acute kidney injury in the setting of pediatric trauma: a trauma quality improvement program analysis.Pediatric nephrology (Berlin, Germany) · 2026Article
- Older age and post-traumatic organ failure a TraumaRegister DGUEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- An interpretable machine-learning model for early prediction of acute kidney injury in polytrauma patients.Frontiers in medicine · 2026Article
- Bimodal distribution of trauma-related acute kidney injury (TrAKI): A clinical review.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2026Review
- Prevalence of acute kidney injury in geriatric patients: Equal contribution of arthroplasty and osteosynthesis of the proximal femur.SAGE open medicine · 2026Article
- Development of a risk calculator for acute kidney injury in trauma patients: an experimental study.Trauma surgery & acute care open · 2026Article
- Role of Urinary Biomarkers TIMP-2 and IGFBP7 in Predicting Acute Kidney Injury in Critically Ill Trauma Patients: A Prospective Observational Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- Kidneys on the Frontline: Nephrologists Tackling the Wilds of Acute Kidney Injury in Trauma Patients-From Pathophysiology to Early Biomarkers.Diagnostics (Basel, Switzerland) · 2025Review
- Extracorporeal pediatric renal replacement therapy: diversifying application beyond kidney failure.Pediatric nephrology (Berlin, Germany) · 2025Review
- Continuous renal replacement therapy for acute kidney injury: a case report.Translational pediatrics · 2025Article
- Incidence, risk factors and outcomes of AKI among trauma patients in a tertiary hospital in south-east, Nigeria.BMC nephrology · 2025Article
- Risk of acute kidney injury following repeated contrast exposure in trauma patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Interdisciplinary Management of Traumatic Injuries to the Kidneys and Urinary Tract Caused by Blunt Abdominopelvic Trauma.Journal of clinical medicine · 2024Review
- Advancements in Trauma-Induced Acute Kidney Injury: Diagnostic and Therapeutic Innovations.Life (Basel, Switzerland) · 2024Review
- Our experience with blast and gunshot induced traumatic vascular injuries at Somalia's major vascular referral center.Scientific reports · 2024Article
- Exploration of potential biomarkers and therapeutic targets for trauma-related acute kidney injury.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2024Review
- Predicting Acute Kidney Injury in Trauma Patients: Biomarkers as Early Indicators.Medical science monitor : international medical journal of experimental and clinical research · 2024Observational
- Motor Scooter Syndrome Revisited: A Case of Delayed Presentation of Traumatic Occlusion of the Common Femoral Artery.Cureus · 2023Article
- Intermittent thoracic resuscitative endovascular balloon occlusion of the aorta improves renal function compared to 60 min continuous application after porcine class III hemorrhage.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Article
- Epidemiology and outcome of an acute kidney injuries in the polytrauma victims admitted at the apex trauma center in Dubai.Acute and critical care · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundInjured patients are at risk of developing acute kidney injury (AKI), which is associated with increased morbidity and mortality. The aim of this study is to describe the incidence, timing, and severity of AKI in a large trauma population, identify risk factors for AKI, and report mortality outcomes.
methodsA prospective observational study of injured adults, who met local criteria for trauma team activation, and were admitted to a UK Major Trauma Centre. AKI was defined by the Kidney Disease Improving Global Outcomes (KDIGO) criteria. Multivariable logistic regression and Cox proportional hazard modelling was used to analyse parameters associated with AKI and mortality.
resultsOf the 1410 patients enrolled in the study, 178 (12.6%) developed AKI. Age; injury severity score (ISS); admission systolic blood pressure, lactate and serum creatinine; units of Packed Red Blood Cells transfused in first 24 hours and administration of nephrotoxic therapy were identified as independent risk factors for the development of AKI. Patients that developed AKI had significantly higher mortality than those with normal renal function (47/178 [26.4%] versus 128/1232 [10.4%]; OR 3.09 [2.12 to 4.53]; p<0.0001). After adjusting for other clinical prognostic factors, AKI was an independent risk factor for mortality.
conclusionsAKI is a frequent complication following trauma and is associated with prolonged hospital length of stay and increased mortality. Future research is needed to improve our ability to rapidly identify those at risk of AKI, and develop resuscitation strategies that preserve renal function in trauma patients.
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