Trial reportPloS one2019
Predicting mortality in patients with suspected sepsis at the Emergency Department; A retrospective cohort study comparing qSOFA, SIRS and National Early Warning Score.
Trial report in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05286918 (Antibiotic Stewardship Through CRP-guided Antibiotic Treatment for Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease), which is not on this map. Cited by 90 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Antibiotic Stewardship Through CRP-guided Antibiotic Treatment for Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)
Who cites it
90 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- A comparison of qSOFA, SIRS and NEWS in predicting the accuracy of mortality in patients with suspected sepsis: A meta-analysis.PloS one · 2022Pooled it
- Pooled it
- Performance of universal early warning scores in different patient subgroups and clinical settings: a systematic review.BMJ open · 2021Pooled it
- National Early Warning Score Does Not Accurately Predict Mortality for Patients With Infection Outside the Intensive Care Unit: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Quick sequential organ failure assessment versus systemic inflammatory response syndrome criteria for emergency department patients with suspected infection.Scientific reports · 2021Trial
- Predictive Performance of Sepsis Scoring Tools for In-Hospital Mortality Among Patients With Suspected Sepsis Presenting to the Colonial War Memorial Hospital Emergency Department, Fiji.Emergency medicine Australasia : EMA · 2026Observational
- qREDS score compared with the REDS and NEWS2 scores to risk-stratify emergency department suspected sepsis patients for in-hospital mortality and 168-hour survival probability: a retrospective cohort study.BMJ open quality · 2026Article
- Serum Albumin, Globulin and Albumin-Globulin Ratios as Biomarkers of Clinical Outcomes in COVID-19 Pneumonia.Journal of personalized medicine · 2026Article
- Article
- Artificial intelligence-driven cluster analysis for identifying clinical phenotypes in suspected sepsis patients in the emergency department.BMC emergency medicine · 2026Article
- Development of a machine learning model for predicting urosepsis after ureteroscopic lithotripsy.Urolithiasis · 2026Article
- A Real-Time Prospective Evaluation of the Prognostic Accuracy of SIRS, MEWS, NEWS2 and qSOFA in Predicting ICU Admission and Mortality in an Emergency Department: Implications for Nursing Practice.Nursing in critical care · 2026Observational
- Search for novel biomarkers of febrile neutropenia in hematological patients: an overview.Clinical and experimental medicine · 2025Review
- Respiratory National Early Warning Score for 28-day mortality prediction in suspected sepsis patients in the emergency department.BMC emergency medicine · 2025Article
- External validation of the International Early Warning Score in non-traumatic emergency department patients: a prospective cohort study.BMC emergency medicine · 2025Observational
- Temporal validation of the Ramathibodi Older Sepsis Score (ROSS) for predicting 28-day mortality of older sepsis patients in the emergency department.BMC emergency medicine · 2025Article
- Performance of Early Sepsis Screening Tools for Timely Diagnosis and Antibiotic Stewardship in a Resource-Limited Thai Community Hospital.Antibiotics (Basel, Switzerland) · 2025Article
- Evaluating Sepsis Mortality Predictions from the Emergency Department: A Retrospective Cohort Study Comparing qSOFA, the National Early Warning Score, and the International Early Warning Score.Journal of clinical medicine · 2025Article
- A novel scoring system for evaluating mortality risk of patients with sepsis during early hospitalization.BMC infectious diseases · 2025Article
- Human neutrophil lipocalin, procalcitonin, c-reactive protein, and leucocyte count for prediction of bacterial sepsis in emergency department patients.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn hospitalized patients, the risk of sepsis-related mortality can be assessed using the quick Sepsis-related Organ Failure Assessment (qSOFA). Currently, different tools that predict deterioration such as the National Early Warning Score (NEWS) have been introduced in clinical practice in Emergency Departments (ED) worldwide. It remains ambiguous which screening tool for mortality at the ED is best. The objective of this study was to evaluate the predictive performance for mortality of two sepsis-based scores (i.e. qSOFA and Systemic Inflammatory Response Syndrome (SIRS)-criteria) compared to the more general NEWS score, in patients with suspected infection directly at presentation to the ED.
methodsWe performed a retrospective cohort study. Patients who presented to the ED between June 2012 and May 2016 with suspected sepsis in a large tertiary care center were included. Suspected sepsis was defined as initiation of intravenous antibiotics and/or collection of any culture in the ED. Outcome was defined as 10-day and 30-day mortality after ED presentation. Predictive performance was expressed as discrimination (AUC) and calibration using Hosmer-Lemeshow goodness-of-fit test. Subsequently, sensitivity, and specificity were calculated.
resultsIn total 8,204 patients were included of whom 286 (3.5%) died within ten days and 490 (6.0%) within 30 days after presentation. NEWS had the best performance, followed by qSOFA and SIRS (10-day AUC: 0.837, 0.744, 0.646, 30-day AUC: 0.779, 0.697, 0.631). qSOFA (≥2) lacked a high sensitivity versus SIRS (≥2) and NEWS (≥7) (28.5%, 77.2%, 68.0%), whilst entailing highest specificity versus NEWS and SIRS (93.7%, 66.5%, 37.6%).
conclusionsNEWS is more accurate in predicting 10- and 30-day mortality than qSOFA and SIRS in patients presenting to the ED with suspected sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.