Observational studyPloS one2019
Antagonist muscle activity during reactive balance responses is elevated in Parkinson's disease and in balance impairment.
Observational study in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Pooled it
- Strategic alterations of posture are delayed in Parkinson's disease patients during deep brain stimulation.Scientific reports · 2021Trial
- Altered Neuromuscular Time-Frequency Organization During Sit-to-Walk in Parkinson's Disease: An Explainable Artificial Intelligence Approach Using Surface Electromyography.Sensors (Basel, Switzerland) · 2026Article
- Article
- The Effects of Adapted Tango on Dynamic Balance and Dual-Task Performance in Parkinson's Disease.Journal of motor behavior · 2025Article
- Unraveling the threads of stability: A review of the neurophysiology of postural control in Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Review
- Older adults and individuals with Parkinson's disease control posture along suborthogonal directions that deviate from the traditional anteroposterior and mediolateral directions.Scientific reports · 2024Article
- Muscle Coactivation Index during Walking in People with Multiple Sclerosis with Mild Disability, a Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2023Article
- Voluntary muscle coactivation in quiet standing elicits reciprocal rather than coactive agonist-antagonist control of reactive balance.Journal of neurophysiology · 2023Article
- Effects of lower leg muscle quality on gait variability in community-dwelling older and healthy young adults.Journal of physical therapy science · 2022Article
- Improvements in spatiotemporal outcomes, but not in recruitment of automatic postural responses, are correlated with improved step quality following perturbation-based balance training in chronic stroke.Frontiers in sports and active living · 2022Article
- The cortical N1 response to balance perturbation is associated with balance and cognitive function in different ways between older adults with and without Parkinson's disease.Cerebral cortex communications · 2022Article
- Muscle activation strategies of people with early-stage Parkinson's during walking.Journal of neuroengineering and rehabilitation · 2021Article
- Cortical correlates in upright dynamic and static balance in the elderly.Scientific reports · 2021Article
- Abnormal center of mass feedback responses during balance: A potential biomarker of falls in Parkinson's disease.PloS one · 2021Article
- Lower Cognitive Set Shifting Ability Is Associated With Stiffer Balance Recovery Behavior and Larger Perturbation-Evoked Cortical Responses in Older Adults.Frontiers in aging neuroscience · 2021Article
- Functional Recovery in Parkinson's Disease: Current State and Future Perspective.Journal of clinical medicine · 2020Review
- Effect of a Concurrent Cognitive Task, with Stabilizing Visual Information and Withdrawal, on Body Sway Adaptation of Parkinsonian's Patients in an Off-Medication State: A Controlled Study.Sensors (Basel, Switzerland) · 2020Article
- Fifteen Years of Wireless Sensors for Balance Assessment in Neurological Disorders.Sensors (Basel, Switzerland) · 2020Review
- Perception of whole-body motion during balance perturbations is impaired in Parkinson's disease and is associated with balance impairment.Gait & posture · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAbnormal antagonist leg muscle activity could indicate increased muscle co-contraction and clarify mechanisms of balance impairments in Parkinson's disease (PD). Prior studies in carefully selected patients showed PD patients demonstrate earlier, longer, and larger antagonist muscle activation during reactive balance responses to perturbations. RESEARCH QUESTION: Here, we tested whether antagonist leg muscle activity was abnormal in a group of PD patients who were not selected for phenotype and most of whom had volunteered for exercise-based rehabilitation.
methodsWe compared antagonist activation during reactive balance responses to multidirectional support-surface translation perturbations in 31 patients with mild-moderate PD (age 68±9; H&Y 1-3; UPDRS-III 32±10) and 13 matched individuals (age 65±9). We quantified modulation of muscle activity (i.e., the ability to activate and inhibit muscles appropriately according to the perturbation direction) using modulation indices (MI) derived from minimum and maximum EMG activation levels observed across perturbation directions.
resultsAntagonist leg muscle activity was abnormal in unselected PD patients compared to controls. Linear mixed models identified significant associations between impaired modulation and PD (P<0.05) and PD severity (P<0.01); models assessing the entire sample without referencing PD status identified associations with balance ability (P<0.05), but not age (P = 0.10). SIGNIFICANCE: Antagonist activity is increased during reactive balance responses in PD patients who are not selected on phenotype and are candidates for exercise-based rehabilitation. This activity may be a mechanism of balance impairment in PD and a potential rehabilitation target or outcome measure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.