ArticlePLoS biology2019
Environment-dependent pleiotropic effects of mutations on the maximum growth rate r and carrying capacity K of population growth.
Article in PLoS biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Consistent and idiosyncratic pleiotropy in shaping genetic correlations.Molecular biology and evolution · 2026Article
- Spontaneous mutation rate and spectrum are modulated by organismal fitness.Science advances · 2026Article
- Adaptation without Dominance in Pseudomonas syringae Pathovars.Microbial ecology · 2025Article
- Adaptive tracking with antagonistic pleiotropy results in seemingly neutral molecular evolution.Nature ecology & evolution · 2025Article
- Predicting natural variation in the yeast phenotypic landscape with machine learning.Molecular systems biology · 2025Article
- Effects of resource packaging on the adaptative and pleiotropic consequences of evolution.NPJ systems biology and applications · 2025Article
- Resource presentation dictates genetic and phenotypic adaptation in yeast.BMC ecology and evolution · 2025Article
- Evolution Under Competition Increases Population Production by Reducing the Density-Dependence of Net Energy Fluxes and Growth.Ecology and evolution · 2025Article
- Trait and plasticity evolution under competition and mutualism in evolving pairwise yeast communities.PloS one · 2025Article
- Quantifying the strength of viral fitness trade-offs between hosts: a meta-analysis of pleiotropic fitness effects.Evolution letters · 2024Article
- Relationships between intrinsic population growth rate, carrying capacity and metabolism in microbial populations.The ISME journal · 2023Review
- Patterns and evolutionary consequences of pleiotropy.Annual review of ecology, evolution, and systematics · 2023Article
- Detecting natural selection in trait-trait coevolution.BMC ecology and evolution · 2023Article
- What Has Genomics Taught An Evolutionary Biologist?Genomics, proteomics & bioinformatics · 2023Review
- Complex genetics cause and constrain fungal persistence in different parts of the mammalian body.Genetics · 2022Article
- Synergistic epistasis enhances the co-operativity of mutualistic interspecies interactions.The ISME journal · 2021Article
- Correlational selection in the age of genomics.Nature ecology & evolution · 2021Review
- Caution in testing phenotypic selection.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Interspecific hybrids show a reduced adaptive potential under DNA damaging conditions.Evolutionary applications · 2021Article
- Variation in the life history strategy underlies functional diversity of tumors.National science review · 2021Article
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2 authors.
Funding
Abstract
Maximum growth rate per individual (r) and carrying capacity (K) are key life-history traits that together characterize the density-dependent population growth and therefore are crucial parameters of many ecological and evolutionary theories such as r/K selection. Although r and K are generally thought to correlate inversely, both r/K tradeoffs and trade-ups have been observed. Nonetheless, neither the conditions under which each of these relationships occur nor the causes of these relationships are fully understood. Here, we address these questions using yeast as a model system. We estimated r and K using the growth curves of over 7,000 yeast recombinants in nine environments and found that the r-K correlation among genotypes changes from 0.53 to -0.52 with the rise of environment quality, measured by the mean r of all genotypes in the environment. We respectively mapped quantitative trait loci (QTLs) for r and K in each environment. Many QTLs simultaneously influence r and K, but the directions of their effects are environment dependent such that QTLs tend to show concordant effects on the two traits in poor environments but antagonistic effects in rich environments. We propose that these contrasting trends are generated by the relative impacts of two factors-the tradeoff between the speed and efficiency of ATP production and the energetic cost of cell maintenance relative to reproduction-and demonstrate an agreement between model predictions and empirical observations. These results reveal and explain the complex environment dependency of the r-K relationship, which bears on many ecological and evolutionary phenomena and has biomedical implications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.