Evidence map›Paper›PMID 30681867›Full record

ArticleMolecular pharmaceutics2019

Soluble Antigen Arrays for Selective Desensitization of Insulin-Reactive B Cells.

Martin A Leon, Scott M Wemlinger, Nicholas R Larson, Justin K Ruffalo, Joshua O Sestak, C Russell Middaugh, John C Cambier, Cory Berkland

Open access · greenAbstract read
In one paragraph

Article in Molecular pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Estrogen and viral infection.Frontiers in immunology · 2025
    Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Biomaterial Strategies for Selective Immune Tolerance: Advances and Gaps.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  9. Article
  10. Review
  11. Review
  12. Roles of TLR7 inFrontiers in cellular and infection microbiology · 2021
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Martin A LeonDepartment of Chemistry , University of Kansas , 1251 Wescoe Hall Drive , Lawrence , Kansas 66045 , United States.ORCID 0000-0002-8992-6306
Scott M WemlingerDepartment Immunology & Microbiology , University of Colorado Denver AMC , 12800 E. 19th Ave. , Aurora , Colorado 80045 , United States.
Nicholas R LarsonDepartment of Pharmaceutical Chemistry , University of Kansas , 2095 Constant Avenue , Lawrence , Kansas 66047 , United States.ORCID 0000-0001-9364-9594
Justin K RuffaloDepartment of Chemical and Petroleum Engineering , University of Kansas , 1530 West 15th Street , Lawrence , Kansas 66045 , United States.
Joshua O SestakOrion BioScience , 986099 Nebraska Medical Center , Omaha , Nebraska 68198 , United States.
C Russell MiddaughDepartment of Pharmaceutical Chemistry , University of Kansas , 2095 Constant Avenue , Lawrence , Kansas 66047 , United States.
John C CambierDepartment Immunology & Microbiology , University of Colorado Denver AMC , 12800 E. 19th Ave. , Aurora , Colorado 80045 , United States.
Cory BerklandDepartment of Chemistry , University of Kansas , 1251 Wescoe Hall Drive , Lawrence , Kansas 66045 , United States.ORCID 0000-0002-9346-938X
University of Kansas · USUniversity of Colorado Denver · USNebraska Medical Center · US

Funding

TRAINING GRANT IN DYNAMIC ASPECTS OF CHEMICAL BIOLOGYT32GM008545 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI LAMB, AUDREY L · 1994 to 2019
$4.9M
Autoimmunity risk alleles compromising B cell anergyR01AI124487 · NIAID · UNIVERSITY OF COLORADO DENVER · PI CAMBIER, JOHN C · 2016 to 2020
$2.5M
NIGMS NIH HHS T32 GM008545
6 · The paper itself

Abstract

Autoimmune diseases are believed to be highly dependent on loss of immune tolerance to self-antigens. Currently, no treatments have been successful clinically in inducing autoantigen-specific tolerance, including efforts to utilize antigen-specific immunotherapy (ASIT) to selectively correct the aberrant autoimmunity. Soluble antigen arrays (SAgAs) represent a novel autoantigen delivery system composed of a linear polymer, hyaluronic acid (HA), displaying multiple copies of conjugated autoantigen. We have previously reported that soluble antigen arrays displaying proteolipid peptide (SAgA

Indexed as

AnimalsAutoantigensB-LymphocytesDiabetes Mellitus, Type 1FemaleHumansHyaluronic AcidImmune ToleranceInsulinMiceMice, Inbred NODMultiple SclerosisPeptide FragmentsProtein Array AnalysisReceptors, Antigen, B-CellAutoantigensHyaluronic AcidInsulinPeptide FragmentsReceptors, Antigen, B-Cellanergizedautoimmune diseasesB cell antigen receptorsepitopeex vivoinsulinsoluble antigen arraytolerancetype 1 diabetesvalency

Identifiers

PMID30681867
PMCPMC7446942
OpenAlexW2914480877

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.