Evidence map›Paper›PMID 30681850›Full record

ArticleJournal of the American Chemical Society2019

Cyclometalated Iridium-PhanePhos Complexes Are Active Catalysts in Enantioselective Allene-Fluoral Reductive Coupling and Related Alcohol-Mediated Carbonyl Additions That Form Acyclic Quaternary Carbon Stereocenters.

Leyah A Schwartz, Michael Holmes, Gilmar A Brito, Théo P Gonçalves, Jeffery Richardson, J Craig Ruble, Kuo-Wei Huang, Michael J Krische

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Chiral Spiro-Scaffolded C(spAngewandte Chemie (International ed. in English) · 2026
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  18. MultilayerResearch (Washington, D.C.) · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Leyah A SchwartzDepartment of Chemistry , University of Texas at Austin , Austin , Texas 78712 , United States.
Michael HolmesDepartment of Chemistry , University of Texas at Austin , Austin , Texas 78712 , United States.
Gilmar A BritoDepartment of Chemistry , University of Texas at Austin , Austin , Texas 78712 , United States.
Théo P GonçalvesKAUST Catalysis Center and Division of Physical Sciences and Engineering , King Abdullah University of Science and Technology (KAUST) , Thuwal 23955-6900 , Saudi Arabia.
Jeffery RichardsonDiscovery Chemistry Research and Technologies , Eli Lilly and Company Limited , Erl Wood Manor , Windlesham , Surrey GU20 6PH , United Kingdom.ORCID 0000-0002-4450-3828
J Craig RubleDiscovery Chemistry Research and Technologies , Eli Lilly and Company , Indianapolis , Indiana 46285 , United States.ORCID 0000-0002-9551-1529
Kuo-Wei HuangKAUST Catalysis Center and Division of Physical Sciences and Engineering , King Abdullah University of Science and Technology (KAUST) , Thuwal 23955-6900 , Saudi Arabia.ORCID 0000-0003-1900-2658
Michael J KrischeDepartment of Chemistry , University of Texas at Austin , Austin , Texas 78712 , United States.ORCID 0000-0001-8418-9709

Funding

Substituted Piperidine Formation via C-C Bond Forming Transfer HydrogenationR01GM069445 · NIGMS · UNIVERSITY OF TEXAS AUSTIN · PI KRISCHE, MICHAEL J · 2005 to 2024
$6.7M
Bruker AVANCE III HD 500 MHz NMRS10OD021508 · OD · UNIVERSITY OF TEXAS AT AUSTIN · PI SESSLER, JONATHAN L · 2016 to 2016
$529k
NIGMS NIH HHS R01 GM069445NIH HHS S10 OD021508
6 · The paper itself

Abstract

Iridium complexes modified by the chiral phosphine ligand PhanePhos catalyze the 2-propanol-mediated reductive coupling of diverse 1,1-disubstituted allenes 1a-1u with fluoral hydrate 2a to form CF

Indexed as

AlcoholsAlkadienesAllyl CompoundsCarbonCatalysisHydrocarbons, FluorinatedIridiumKineticsLigandsMolecular StructureOrganometallic CompoundsOxidation-ReductionPhosphinesStereoisomerismThermodynamicsAlcoholsAlkadienesAllyl CompoundsCarbonHydrocarbons, FluorinatedIridiumLigandsOrganometallic CompoundsphosphinePhosphines

Identifiers

PMID30681850
PMCPMC6423978

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.