Evidence map›Paper›PMID 30681752›Full record

ArticleStem cells (Dayton, Ohio)2019

Periarticular Mesenchymal Progenitors Initiate and Contribute to Secondary Ossification Center Formation During Mouse Long Bone Development.

Wei Tong, Robert J Tower, Chider Chen, Luqiang Wang, Leilei Zhong, Yulong Wei, Hao Sun, Gaoyuan Cao, Haoruo Jia, Maurizio Pacifici and 3 more

Open access · greenAbstract read
In one paragraph

Article in Stem cells (Dayton, Ohio), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 36 citations in OpenAlex.

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  11. The Critical Role of The Piezo1/β-catenin/ATF4 Axis on The Stemness of Gli1Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
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  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Wei TongDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Robert J TowerDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-5856-5758
Chider ChenDepartment of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Luqiang WangDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Leilei ZhongDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Yulong WeiDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Hao SunDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Gaoyuan CaoRutgers Institute for Translational Medicine and Science, Rutgers University, New Brunswick, New Jersey, USA.
Haoruo JiaDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Maurizio PacificiTranslational Research Program in Pediatric Orthopaedics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Eiki KoyamaTranslational Research Program in Pediatric Orthopaedics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Motomi Enomoto-IwamotoDepartment of Orthopaedic Surgery, School of Medicine, University of Maryland, Baltimore, Maryland, USA.
Ling QinDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-2582-0078
University of Pennsylvania · USChildren's Hospital of Philadelphia · USUnion Hospital · CNRutgers, The State University of New Jersey · USUniversity of Maryland, Baltimore · US

Funding

Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)P30AR069619 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI LOUIS J SOSLOWSKY · 2016 to 2026
$9.1M
Mechanism of radiotherapy-induced osteoporosis and its treatmentR01AR066098 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI QIN, LING · 2015 to 2019
$1.8M
Role of EGFR signaling in bone formation and the anabolic actions of PTHR01DK095803 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI QIN, LING · 2013 to 2017
$1.7M
NIAMS NIH HHS P30 AR069619NIAMS NIH HHS R01 AR066098NIDDK NIH HHS R01 DK095803
6 · The paper itself

Abstract

Long bone development involves the embryonic formation of a primary ossification center (POC) in the incipient diaphysis followed by postnatal development of a secondary ossification center (SOC) at each epiphysis. Studies have elucidated major basic mechanisms of POC development, but relatively little is known about SOC development. To gain insights into SOC formation, we used Col2-Cre Rosa-tdTomato (Col2/Tomato) reporter mice and found that their periarticular region contained numerous Tomato-positive lineage cells expressing much higher Tomato fluorescence (termed Tomato

Indexed as

Mesenchymal Stem CellsAnimalsBone DevelopmentCartilageCell DifferentiationChondrocytesGene Expression Regulation, DevelopmentalGrowth PlateMiceOsteogenesisSignal TransductionSkullVascular Endothelial Growth Factor AZinc Finger Protein GLI1Gli1 protein, mouseVascular Endothelial Growth Factor Avascular endothelial growth factor A, mouseZinc Finger Protein GLI1Blood vesselCartilageMesenchymal progenitorsPeriarticular layerSecondary ossification center

Identifiers

PMID30681752
PMCPMC6504254
OpenAlexW2914038060

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.