ArticleExperimental dermatology2019
Self-organizing hair peg-like structures from dissociated skin progenitor cells: New insights for human hair follicle organoid engineering and Turing patterning in an asymmetric morphogenetic field.
Article in Experimental dermatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Hair follicle organoids: advances in construction, applications, and translational challenges.Frontiers in cell and developmental biology · 2026Review
- Organoids in skin wound healing.Burns & trauma · 2025Review
- Review
- Potential application of PBM use in hair follicle organoid culture for the treatment of androgenic alopecia.Materials today. Bio · 2023Review
- Epidermal-dermal coupled spheroids are important for tissue pattern regeneration in reconstituted skin explant cultures.NPJ Regenerative medicine · 2023Article
- The mechano-chemical circuit drives skin organoid self-organization.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Biofabrication of Human Skin with Its Appendages.Advanced healthcare materials · 2022Review
- Adaptive multi-degree-of-freedom in situ bioprinting robot for hair-follicle-inclusive skin repair: A preliminary study conducted in mice.Bioengineering & translational medicine · 2022Article
- Global Research Status and Trends in Hair Follicle Stem Cells: a Bibliometric Analysis.Stem cell reviews and reports · 2022Article
- Self-assembled complete hair follicle organoids by coculture of neonatal mouse epidermal cells and dermal cells in Matrigel.Annals of translational medicine · 2022Article
- Biomaterials and bioengineering to guide tissue morphogenesis in epithelial organoids.Frontiers in bioengineering and biotechnology · 2022Review
- Skin organoids: A new human model for developmental and translational research.Experimental dermatology · 2021Article
- Bespoke Turing Systems.Bulletin of mathematical biology · 2021Article
- Fostering a healthy culture: Biological relevance of in vitro and ex vivo skin models.Experimental dermatology · 2021Article
- More than just bricks and mortar: Fibroblasts and ECM in skin health and disease.Experimental dermatology · 2021Article
- "Two-Cell Assemblage" Assay: A SimpleFrontiers in cell and developmental biology · 2020Article
- From one pattern into another: analysis of Turing patterns in heterogeneous domains via WKBJ.Journal of the Royal Society, Interface · 2020Article
- Pre-aggregation of scalp progenitor dermal and epidermal stem cells activates the WNT pathway and promotes hair follicle formation in in vitro and in vivo systems.Stem cell research & therapy · 2019Article
- Understanding skin morphogenesis across developmental, regenerative and evolutionary levels.Experimental dermatology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 4 countries.
Funding
Abstract
Human skin progenitor cells will form new hair follicles, although at a low efficiency, when injected into nude mouse skin. To better study and improve upon this regenerative process, we developed an in vitro system to analyse the morphogenetic cell behaviour in detail and modulate physical-chemical parameters to more effectively generate hair primordia. In this three-dimensional culture, dissociated human neonatal foreskin keratinocytes self-assembled into a planar epidermal layer while fetal scalp dermal cells coalesced into stripes, then large clusters, and finally small clusters resembling dermal condensations. At sites of dermal clustering, subjacent epidermal cells protruded to form hair peg-like structures, molecularly resembling hair pegs within the sequence of follicular development. The hair peg-like structures emerged in a coordinated, formative wave, moving from periphery to centre, suggesting that the droplet culture constitutes a microcosm with an asymmetric morphogenetic field. In vivo, hair follicle populations also form in a progressive wave, implying the summation of local periodic patterning events with an asymmetric global influence. To further understand this global patterning process, we developed a mathematical simulation using Turing activator-inhibitor principles in an asymmetric morphogenetic field. Together, our culture system provides a suitable platform to (a) analyse the self-assembly behaviour of hair progenitor cells into periodically arranged hair primordia and (b) identify parameters that impact the formation of hair primordia in an asymmetric morphogenetic field. This understanding will enhance our future ability to successfully engineer human hair follicle organoids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.