Observational studyASAIO journal (American Society for Artificial Internal Organs : 1992)2020
Neurologic Outcomes in a Two-Center Cohort of Neonatal and Pediatric Patients Supported on Extracorporeal Membrane Oxygenation.
Observational study in ASAIO journal (American Society for Artificial Internal Organs : 1992), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Brain development in newborns and infants after ECMO.World journal of pediatrics : WJP · 2024Pooled it
- Neurocognitive functioning and health-related quality of life of children after pediatric intensive care admission: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Pooled it
- Ultra-Low-Field Portable Magnetic Resonance Imaging Feasibility and Safety in Pediatric and Neonatal Extracorporeal Membrane Oxygenation: A Single-Center Year-Long Experience.Journal of the American Heart Association · 2025Trial
- Development of a pediatric pig model of extracorporeal cardiopulmonary resuscitation-induced acute kidney injury.Disease models & mechanisms · 2026Article
- Follow-up of neonates who received ECMO: how are they doing?European journal of pediatrics · 2026Review
- Exploratory deep-learning-driven early risk stratification of significant neurological injury in pediatric extracorporeal membrane oxygenation.Frontiers in digital health · 2026Article
- Plasma brain-related biomarkers and potential therapeutic targets in pediatric ECMO.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Standardized therapies after ECMO program (STEP); a novel approach to pediatric post-ECMO care.The journal of extra-corporeal technology · 2024Article
- Higher levels of brain injury biomarker tau are associated with unfavorable outcomes in patients supported with ECMO following cardiac arrest.Resuscitation plus · 2024Article
- Exploratory factor analysis yields grouping of brain injury biomarkers significantly associated with outcomes in neonatal and pediatric ECMO.Scientific reports · 2024Article
- Neuromonitoring During ECMO Support in Children.Neurocritical care · 2023Review
- Review of Noninvasive Neuromonitoring Modalities in Children II: EEG, qEEG.Neurocritical care · 2023Review
- Lessons Learned in Neurodevelopmental Outcomes Research in Children Following Extracorporeal Membrane Oxygenation.Journal of neurosurgical anesthesiology · 2023Review
- Cognitive and Psychological Outcomes Following Pediatric Cardiac Arrest.Frontiers in pediatrics · 2022Review
- ECMO in neonates: The association between cerebral hemodynamics with neurological function.Frontiers in pediatrics · 2022Review
- Bridging the Gap Between Intensivists and Primary Care Clinicians in Extracorporeal Membrane Oxygenation for Respiratory Failure in Children: A Review.JAMA pediatrics · 2021Review
- Neural Networks to Predict Radiographic Brain Injury in Pediatric Patients Treated with Extracorporeal Membrane Oxygenation.Journal of clinical medicine · 2020Article
- Neurological Monitoring and Complications of Pediatric Extracorporeal Membrane Oxygenation Support.Pediatric neurology · 2020Review
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Authors and funding
11 authors.
Funding
Abstract
Contemporary studies of long-term outcomes in children supported on extracorporeal membrane oxygenation (ECMO) in the United States are limited. We enrolled 99 ECMO patients between July 2010 and June 2015 in a two-center prospective observational study that included neurologic and neuropsychologic evaluation at 6 and 12 months, using standardized outcome measures. Pre-ECMO, 20 (20%) had a pre-existing neurologic diagnosis, 40 (40%) had cardiac arrest, and 10 of 47 (21%) children with neuroimaging had acute abnormal findings. Of 50 children eligible for follow-up at 6 or 12 months, 40 (80%) returned for at least one visit. At the follow-up visit of longest interval from ECMO, the median Vineland Adaptive Behavior Scales-II (VABS-II) score was 91 (interquartile range [IQR], 81-98), the median Pediatric Stroke Outcome Measure (PSOM) score was 1 (IQR, 0-2), and the median Mullen Scales of Early Learning composite score was 85 (IQR, 72-96). Presence of new neuroimaging abnormalities during ECMO or within 6 weeks post-ECMO was associated with VABS-II score <85 or death within 12 months after ECMO. The Pediatric Cerebral Performance Category at hospital discharge showed a strong relationship with unfavorable VABS-II and PSOM scores at 6 or 12 months after ECMO. In this study, we report a higher prevalence of pre-ECMO neurologic conditions than previously described. In survivors to hospital discharge, median scores for adaptive behavior and cognitive, neurologic, and quality of life assessments were all below the general population means, but most deficits would be considered minor within each of the domains tested.
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