Evidence map›Paper›PMID 30681372›Full record

ReviewAmerican journal of respiratory and critical care medicine2019

The Genetics of Pneumothorax.

Philip M Boone, Rachel M Scott, Stefan J Marciniak, Elizabeth P Henske, Benjamin A Raby

Open access · greenAbstract readReview
In one paragraph

Review in American journal of respiratory and critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.

  1. Pooled it
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  6. Review
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  10. Review
  11. New strategies in the management of pneumothorax.Breathe (Sheffield, England) · 2025
    Review
  12. Article
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Philip M Boone1 Harvard Genetics Training Program, Boston, Massachusetts.ORCID 0000-0001-9528-252X
Rachel M Scott3 Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Stefan J Marciniak3 Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Elizabeth P Henske5 Pulmonary Genetics Center, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; and.
Benjamin A Raby5 Pulmonary Genetics Center, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; and.
Brigham and Women's Hospital · USUniversity of Cambridge · GBMassachusetts General Hospital · US

Funding

Systems Biology of Airway DiseaseP01HL132825 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2016 to 2020
$12.6M
Clinical Genetics and Screening for Pulmonary FibrosisR01HL130974 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GARY MATTHEW HUNNINGHAKE, Benjamin Alexander Raby · 2016 to 2026
$10.0M
The Integrative Genomics of Acute Asthma ControlR01HL118455 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MILLSTEIN, JOSHUA, RABY, BENJAMIN ALEXANDER · 2014 to 2024
$6.5M
The Molecular and Genetic Pathogensis of LAMU01HL131022 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HENSKE, ELIZABETH P · 2016 to 2024
$5.7M
The Functional Consequences of the 17q12 Asthma Susceptibility LocusR01HL123546 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI RABY, BENJAMIN ALEXANDER · 2015 to 2018
$3.4M
Induction of Oncogenic mircoRNA by rapamycin: Role in TSC TherapyR01DK102146 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI HENSKE, ELIZABETH P · 2015 to 2019
$1.9M
Medical Research Council G0601840Medical Research Council G1002610Medical Research Council MR/R009120/1NHLBI NIH HHS P01 HL132825NHLBI NIH HHS R01 HL118455NHLBI NIH HHS R01 HL123546NHLBI NIH HHS R01 HL130974NHLBI NIH HHS U01 HL131022NIDDK NIH HHS R01 DK102146
6 · The paper itself

Abstract

A genetic influence on spontaneous pneumothoraces-those occurring without a traumatic or iatrogenic cause-is supported by several lines of evidence:

Indexed as

Birt-Hogg-Dube SyndromeGenetic Predisposition to DiseaseGenetic TestingHumansMutationPedigreePneumothoraxProto-Oncogene ProteinsTumor Suppressor ProteinsFLCN protein, humanProto-Oncogene ProteinsTumor Suppressor ProteinsBirt-Hogg-Dubé syndromefamilial spontaneous pneumothoraxgenegeneticspneumothorax

Identifiers

PMID30681372
PMCPMC6543724
OpenAlexW2914401041

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.