ArticleChemistry (Weinheim an der Bergstrasse, Germany)2019
Cyclooctatetraene: A Bioactive Cubane Paradigm Complement.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- A Click-Type Reaction of (RRR)-α-Tocopherol and Related 6-Chromanols Allowing a One Pot Derivatisation of All Fat-Soluble Vitamins.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Small-molecule inhibition of γ-glutamyl carboxylase reveals a novel anticoagulant strategy.Blood advances · 2026Article
- Probing three-dimensional cyclooctatetraene for nucleobase modification in aptamer selection.Communications chemistry · 2025Article
- The Baeyer-Villiger Oxidation of Cubyl Ketones: A Synthetic Route to Functionalized Cubanols.Organic letters · 2025Article
- Three-dimensional saturated C(spNature reviews. Chemistry · 2024Review
- Naturally occurring UBIAD1 mutations differentially affect menaquinone biosynthesis and vitamin K-dependent carboxylation.The FEBS journal · 2022Article
- Targeting multiple enzymes in vitamin K metabolism for anticoagulation.Journal of thrombosis and haemostasis : JTH · 2021Article
- A novel vitamin K derived anticoagulant tolerant to genetic variations of vitamin K epoxide reductase.Journal of thrombosis and haemostasis : JTH · 2021Article
- Cubane Electrochemistry: Direct Conversion of Cubane Carboxylic Acids to Alkoxy Cubanes Using the Hofer-Moest Reaction under Flow Conditions.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Determining the necessity of phenyl ring π-character in warfarin.Bioorganic & medicinal chemistry letters · 2019Article
Corrections and comments
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Authors and funding
23 authors.
Funding
Abstract
Cubane was recently validated as a phenyl ring (bio)isostere, but highly strained caged carbocyclic systems lack π character, which is often critical for mediating key biological interactions. This electronic property restriction associated with cubane has been addressed herein with cyclooctatetraene (COT), using known pharmaceutical and agrochemical compounds as templates. COT either outperformed or matched cubane in multiple cases suggesting that versatile complementarity exists between the two systems for enhanced bioactive molecule discovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.