Evidence map›Paper›PMID 30681235›Full record

ArticleDepression and anxiety2019

Differentiating PTSD from anxiety and depression: Lessons from the ICD-11 PTSD diagnostic criteria.

Anna C Barbano, Willem F van der Mei, Terri A deRoon-Cassini, Ettie Grauer, Sarah Ryan Lowe, Yutaka J Matsuoka, Meaghan O'Donnell, Miranda Olff, Wei Qi, Andrew Ratanatharathorn and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Depression and anxiety, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Article
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  6. Post-traumatic stress disorder.Nature reviews. Disease primers · 2026
    Review
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  8. Weight Suppression and Risk for Childhood Psychiatric Disorders.Child psychiatry and human development · 2025
    Article
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  10. Dopamine modulation of basolateral amygdala activity and function.Journal of computational neuroscience · 2025
    Article
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 6 countries.

Anna C BarbanoDepartment of Psychiatry, New York University School of Medicine, New York, New York.ORCID 0000-0002-0581-1537
Willem F van der MeiDepartment of Psychiatry, New York University School of Medicine, New York, New York.ORCID 0000-0002-6396-3790
Terri A deRoon-CassiniDepartment of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.ORCID 0000-0002-9485-0625
Ettie GrauerDepartment of Psychiatry, New York University School of Medicine, New York, New York.ORCID 0000-0001-9375-6541
Sarah Ryan LoweDepartment of Psychology, Montclair State University, Montclair, New Jersey.ORCID 0000-0001-9544-4234
Yutaka J MatsuokaDivision of Health Care Research, Center for Public Health Sciences, National Cancer Center Japan, Tokyo, Japan.ORCID 0000-0002-8690-8129
Meaghan O'DonnellPheonix Australia, Department of Psychiatry, The University of Melbourne, Parkville, Australia.ORCID 0000-0003-4349-0022
Miranda OlffDepartment of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0003-1016-9515
Wei QiDepartment of Psychiatry, New York University School of Medicine, New York, New York.ORCID 0000-0003-3727-1616
Andrew RatanatharathornDepartment of Epidemiology, Columbia University Mailman School of Public Health, New York, New York.ORCID 0000-0001-9855-0438
Ulrich SchnyderDepartment of Psychiatry, University of Zurich, Zürich, Switzerland.ORCID 0000-0003-3556-7990
Soraya SeedatDepartment of Psychiatry, Stellenbosch University, Cape Town, South Africa.ORCID 0000-0002-5118-786X
Ronald C KesslerDepartment of Health Care Policy, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0003-4831-2305
Karestan C KoenenDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.ORCID 0000-0003-2978-7655
Arieh Y ShalevDepartment of Psychiatry, New York University School of Medicine, New York, New York.ORCID 0000-0001-9425-050X
International Consortium to Prevent PTSD
New York University · USArq Psychotrauma Expert Group · NLHarvard University · USMassachusetts Department of Public Health · USMedical College of Wisconsin · USMontclair State University · USNational Center for Global Health and Medicine · JPThe University of Melbourne · AUUniversity of Cape Town · ZAUniversity of Zurich · CH

Funding

Training Program in Psychiatric Genetics and Translational ResearchT32MH017119 · NIMH · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI KARESTAN C KOENEN, Jukka-Pekka Onnela · 1985 to 2026
$8.9M
Identifying Risk Factors for PTSD by Pooled Analysis of Current Prospective StudiR01MH101227 · NIMH · HARVARD SCHOOL OF PUBLIC HEALTH · PI KESSLER, RONALD C, KOENEN, KARESTAN C · 2014 to 2017
$2.7M
NIMH NIH HHS R01 MH101227NIMH NIH HHS T32 MH017119
6 · The paper itself

Abstract

objectivePosttraumatic stress disorder (PTSD) is frequently associated with depression and anxiety, but the nature of the relationship is unclear. By removing mood and anxiety diagnostic criteria, the 11th edition of the International Classification of Diseases (ICD-11) aims to delineate a distinct PTSD phenotype. We examined the effect of implementing ICD-11 criteria on rates of codiagnosed depression and anxiety in survivors with recent PTSD.

methodParticipants were 1,061 survivors of traumatic injury admitted to acute care centers in Israel. ICD-10 and ICD-11 diagnostic rules were applied to the Clinician-Administered PTSD Scale for DSM-IV. Co-occurring disorders were identified using the Structured Clinical Interview for DSM-IV (SCID). Depression severity was measured by the Beck Depression Inventory-II (BDI-II). Assessments were performed 0-60 ("wave 1") and 90-240 ("wave 2") days after trauma exposure.

resultsParticipants identified by ICD-11 PTSD criteria were equally or more likely than those identified by the ICD-10 alone to meet depression or anxiety disorder diagnostic criteria (for wave 1: depressive disorders, OR [odds ratio] = 1.98, 95% CI [confidence interval] = [1.36, 2.87]; anxiety disorders, OR = 1.04, 95% CI = [0.67, 1.64]; for wave 2: depressive disorders, OR = 1.70, 95% CI = [1.00, 2.91]; anxiety disorders, OR = 1.04, 95% CI = [0.54, 2.01]). ICD-11 PTSD was associated with higher BDI scores (M = 23.15 vs. 17.93, P < 0.001 for wave 1; M = 23.93 vs. 17.94, P < 0.001 for wave 2). PTSD symptom severity accounted for the higher levels of depression in ICD-11 PTSD.

conclusionsDespite excluding depression and anxiety symptom criteria, the ICD-11 identified equal or higher proportion of depression and anxiety disorders, suggesting that those are inherently associated with PTSD.

Indexed as

Diagnostic and Statistical Manual of Mental DisordersInternational Classification of DiseasesAdultAgedAnxietyAnxiety DisordersDepressionDepressive DisorderDiagnosis, DifferentialFemaleHumansIsraelMaleMiddle AgedStress Disorders, Post-TraumaticSurvivorsanxiety disorderscomorbiditydepressive disordersnosologyposttraumatic stress disorder

Identifiers

PMID30681235
PMCPMC6548615
OpenAlexW2913391003

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.