ArticleThe Journal of physiology2019
Region-specific differences and areal interactions underlying transitions in epileptiform activity.
Article in The Journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Neuron-derived neurotrophic factor-positive interneurons: a cellular target for anti-seizure therapies.EBioMedicine · 2026Article
- Seize the Data: A User-Friendly GUI for High-Resolution Analysis of Seizure Dynamics in HD-MEA Recordings.eNeuro · 2026Article
- Interneuron-Driven Ictogenesis in the 4-Aminopyridine Model: Depolarization Block and Potassium Accumulation Initiate Seizure-like Activity.International journal of molecular sciences · 2025Article
- Phylogenetic divergence of GABANature communications · 2025Article
- On brain stimulation in epilepsy.Brain : a journal of neurology · 2025Review
- Focal seizures induce spatiotemporally organized spiking activity in the human cortex.Nature communications · 2024Article
- Article
- Identifying sources of human interictal discharges with travelling wave and white matter propagation.Brain : a journal of neurology · 2023Article
- Cell-type specific and multiscale dynamics of human focal seizures in limbic structures.Brain : a journal of neurology · 2023Article
- Cell-specific NFIA upregulation promotes epileptogenesis by TRPV4-mediated astrocyte reactivity.Journal of neuroinflammation · 2023Article
- Optogenetic stimulation reveals a latent tipping point in cortical networks during ictogenesis.Brain : a journal of neurology · 2023Article
- Interictal discharges in the human brain are travelling waves arising from an epileptogenic source.Brain : a journal of neurology · 2023Article
- Xenon LFP Analysis Platform Is a Novel Graphical User Interface for Analysis of Local Field Potential From Large-Scale MEA Recordings.Frontiers in neuroscience · 2022Article
- Ictal wavefront propagation in slices and simulations with conductance-based refractory density model.PLoS computational biology · 2022Article
- Excitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus.Brain : a journal of neurology · 2019Article
- Acute Focal Seizures Start As Local Synchronizations of Neuronal Ensembles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Divergent paths to seizure-like events.Physiological reports · 2019Article
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Authors and funding
3 authors at 1 institution in 2 countries.
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Abstract
key pointsLocal neocortical and hippocampal territories show different and sterotypical patterns of acutely evolving, epileptiform activity. Neocortical and entorhinal networks show tonic-clonic-like events, but the main hippocampal territories do not, unless it is relayed from the other areas. Transitions in the pattern of locally recorded epileptiform activity can be indicative of a shift in the source of pathological activity, and may spread through both synaptic and non-synaptic means. Hippocampal epileptiform activity is promoted by 4-aminopyridine and inhibited by GABA ABSTRACT: Understanding the nature of epileptic state transitions remains a major goal for epilepsy research. Simple in vitro models offer unique experimental opportunities that we exploit to show that such transitions can arise from shifts in the ictal source of the activity. These transitions reflect the fact that cortical territories differ both in the type of epileptiform activity they can sustain and in their susceptibility to drug manipulation. In the zero-Mg
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