Evidence map›Paper›PMID 30681067›Full record

ArticleMicrobiology spectrum2019

Outer Membrane Vesicle-Host Cell Interactions.

Jessica D Cecil, Natalie Sirisaengtaksin, Neil M O'Brien-Simpson, Anne Marie Krachler

Abstract read
In one paragraph

Article in Microbiology spectrum, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers.

0numbers the graph read from it
0cells of the map it votes in
128citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

128 citing papers in PubMed, 177 citations in OpenAlex.

  1. Trial
  2. Virulence · 2026
    Review
  3. Review
  4. Infection and immunity · 2026
    Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  12. Anti-inflammatory effect ofJournal of animal science and technology · 2026
    Article
  13. Review
  14. Review
  15. SypC, a symbiont outer membrane vesicle protein, impacts the development of the squid-vibrio partnership.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  16. Article
  17. mBio · 2026
    Article
  18. Article
  19. Article
  20. Article

68 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Jessica D CecilOral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Melbourne, Victoria 3052, Australia.
Natalie SirisaengtaksinDepartment of Microbiology and Molecular Genetics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030.
Neil M O'Brien-SimpsonOral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Melbourne, Victoria 3052, Australia.
Anne Marie KrachlerDepartment of Microbiology and Molecular Genetics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030.
The University of Texas Health Science Center at Houston · USUniversity of Melbourne · AU

Funding

Mechanoregulation of EHEC virulenceR01AI132354 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Anne-Marie Krachler · 2018 to 2026
$3.5M
Role of mucin sulfation and sulfation-specific adhesins in AIEC colonizationR21AI151259 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KRACHLER, ANNE-MARIE · 2020 to 2021
$439k
NIAID NIH HHS R01 AI132354NIAID NIH HHS R21 AI151259
6 · The paper itself

Abstract

Outer membrane vesicles (OMVs) are nanosized proteoliposomes derived from the outer membrane of Gram-negative bacteria. They are ubiquitously produced both in culture and during infection and are now recognized to play crucial roles during host-microbe interactions. OMVs can transport a broad range of chemically diverse cargoes, including lipids and lipopolysaccharides, membrane-embedded and associated proteins and small molecules, peptidoglycan, and nucleic acids. Particularly, virulence factors such as adhesins and toxins are often enriched in OMVs. Here we discuss a variety of ways in which OMVs facilitate host-microbe interactions, including their contributions to biofilm formation, nutrient scavenging, and modulation of host cell function. We particularly examine recent findings regarding OMV-host cell interactions in the oral cavity and the gastrointestinal tract.

Indexed as

Bacterial Outer Membrane ProteinsBiological TransportCell MembraneGram-Negative BacteriaHumansLipopolysaccharidesProteolipidsTransport VesiclesBacterial Outer Membrane ProteinsLipopolysaccharidesProteolipidsproteoliposomes

Identifiers

PMID30681067
PMCPMC6352913
OpenAlexW2913159336

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.