Evidence map›Paper›PMID 30680976›Full record

ArticleJournal of biomedical optics2019

Hybrid time-domain and continuous-wave diffuse optical tomography instrument with concurrent, clinical magnetic resonance imaging for breast cancer imaging.

Jeffrey M Cochran, David R Busch, Li Lin, David L Minkoff, Martin Schweiger, Simon Arridge, Arjun G Yodh

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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  9. Fluorescent Graphitic Carbon Nitride (g-CPharmaceuticals (Basel, Switzerland) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jeffrey M CochranUniversity of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania, United States.
David R BuschUniversity of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania, United States.
Li LinUniversity of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania, United States.
David L MinkoffEmory University, Department of Medicine, Atlanta, Georgia, United States.
Martin SchweigerUniversity College London, Centre for Medical Image Computing, London, United Kigdom.
Simon ArridgeUniversity College London, Centre for Medical Image Computing, London, United Kigdom.
Arjun G YodhUniversity of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania, United States.

Funding

WORKSHOP ON ADVANCES IN MUSCULOSKELETAL MRIP41RR002305 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI LICHT, DANIEL JACQUES · 1985 to 2011
$14.7M
Training in Molecular Therapeutics for Pediatric CardiologyT32HL007915 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Robert J Levy, JOSEPH W ROSSANO · 1999 to 2026
$13.4M
Training and DisseminationP41EB015893 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 2012 to 2019
$11.3M
SPATIAL /SPECTRAL TOMOGRAPHY FOR FUNCTIONAL SPECTROSCOPYU54CA105480 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI TROMBERG, BRUCE J · 2003 to 2007
$6.6M
Diffuse Optics for Acute Stroke ManagementR01NS060653 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI YODH, ARJUN G. · 2008 to 2018
$5.5M
Multi-Spectral Parallel-Plate Diffuse Optical Breast TomographyR01EB002109 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI YODH, ARJUN G. · 2003 to 2012
$3.9M
NCI NIH HHS U54 CA105480NCRR NIH HHS P41 RR002305NHLBI NIH HHS T32 HL007915NIBIB NIH HHS P41 EB015893NIBIB NIH HHS R01 EB002109NINDS NIH HHS R01 NS060653
6 · The paper itself

Abstract

Diffuse optical tomography has demonstrated significant potential for clinical utility in the diagnosis and prognosis of breast cancer, and its use in combination with other structural imaging modalities improves lesion localization and the quantification of functional tissue properties. Here, we introduce a hybrid diffuse optical imaging system that operates concurrently with magnetic resonance imaging (MRI) in the imaging suite, utilizing commercially available MR surface coils. The instrument acquires both continuous-wave and time-domain diffuse optical data in the parallel-plate geometry, permitting both absolute assignment of tissue optical properties and three-dimensional tomography; moreover, the instrument is designed to incorporate diffuse correlation spectroscopic measurements for probing tissue blood flow. The instrument is described in detail here. Image reconstructions of a tissue phantom are presented as an initial indicator of the system's ability to accurately reconstruct optical properties and the concrete benefits of the spatial constraints provided by concurrent MRI. Last, we briefly discuss how various data combinations that the instrument could facilitate, including tissue perfusion, can enable more comprehensive assessment of lesion physiology.

Indexed as

Magnetic Resonance ImagingBreast NeoplasmsEquipment DesignFemaleHumansImage Processing, Computer-AssistedImaging, Three-DimensionalOptics and PhotonicsPhantoms, ImagingSpectrophotometryTomography, Opticalbreast cancerdiffuse opticsmagnetic resonance imagingmultimodalityreconstructiontomography

Identifiers

PMID30680976
PMCPMC6345326

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.