ArticleMicrobiologyOpen2019
Vascular access infection by Staphylococcus aureus from removed dialysis accesses.
Article in MicrobiologyOpen, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Molecular Characteristics and Distribution of Virulence Genes amongThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022Article
- Molecular characterization of clinical isolates from vascular access infection: A single-institution study.MicrobiologyOpen · 2020Article
- Case Commentary: Daptomycin Resistance in Staphylococcus argenteus-from Northern Australia to San Francisco.Antimicrobial agents and chemotherapy · 2020Article
- Heterogeneity of Molecular Characteristics amongMicroorganisms · 2020Article
- Vascular access infection by Staphylococcus aureus from removed dialysis accesses.MicrobiologyOpen · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hemodialysis patients are particularly vulnerable to Staphylococcus aureus infection, with the vascular access serving as the site of entry for this formidable pathogen. Patients with arteriovenous grafts (AVGs) and tunneled-cuffed catheters (TCCs) are at elevated risk of S. aureus infection. In this study, we investigated the correlation between the clinical characteristics of S. aureus vascular access infection (VAI), molecular profiles, and the biofilm formation abilities of clinical isolates of S. aureus. We collected samples of methicillin-resistant S. aureus (MRSA), methicillin-sensitive S. aureus (MSSA), and methicillin-sensitive S. argenteus (MSSAg) from patients with S. aureus VAI and patients with other infections. The molecular profiles of the clinical isolates were determined using disk diffusion testing and molecular typing. The biofilm formation ability was determined by microtiter plate assay. In total, 63 S. aureus and 10 S. argenteus isolates were identified: 40 MRSA, 23 MSSA, and ten MSSAg. MRSA was highly prevalent (77.8%) in TCC isolates and was multidrug resistant. Of the 40 MRSA isolates, ST239-SCCmec III was the predominant clone. SCCmec type IV was the predominant type (35%) in isolates from AVGs, while SCCmec type III was prevalent in TCC infection and showed significantly higher biofilm formation ability than types IV and V. In dialysis VAI by S. aureus, patients with TCC were more often infected with MRSA than patients with AVG, and MRSA in TCC-VAI was predominantly SCCmec type III, which had the strongest drug resistance and biofilm formation ability.
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Registered trials
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