Evidence map›Paper›PMID 30680933›Full record

ArticleThe FEBS journal2019

Regulation of mitochondrial ROS production by HIC-5: a common feature of oncogene-induced senescence and tumor invasiveness?

Wolfgang Doppler, Pidder Jansen-Dürr

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The FEBS journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Wolfgang DopplerDivision of Medical Biochemistry, Biocenter, Innsbruck Medical University, Austria.
Pidder Jansen-DürrResearch Institute for Biomedical Aging Research, University of Innsbruck, Austria.
Innsbruck Medical University · ATUniversität Innsbruck · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transformation by the ras oncogene can result in promotion of metastasis as well as induction of senescence via increased tissue remodeling, for example, by matrix metalloproteases. Increased production of mitochondrial reactive oxygen species (mtROS) via NADPH oxidase 4 (NOX4) is implicated in this process. Hydrogen peroxide-inducible clone-5 (HIC-5) is postulated to sense both matrix detachment of transformed cells and intracellular ROS and can inhibit ras signaling via inhibition of NOX4.

Indexed as

Gene Expression Regulation, NeoplasticAnimalsCell Line, TumorCellular SenescenceEpithelial CellsExtracellular MatrixFemaleFocal AdhesionsHeterograftsHumansIntracellular Signaling Peptides and ProteinsLIM Domain ProteinsMatrix Metalloproteinase 9MiceMice, Inbred NODMitochondriaBRAF protein, humanIntracellular Signaling Peptides and ProteinsKRAS protein, humanLIM Domain ProteinsMatrix Metalloproteinase 9MMP9 protein, humanNADPH Oxidase 4NOX4 protein, humanProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)Reactive Oxygen SpeciesTGFB1I1 protein, human

Identifiers

PMID30680933
PMCPMC6850634
OpenAlexW2913819768

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.