Evidence map›Paper›PMID 30680911›Full record

ArticleAging cell2019

Long-term intake of phenolic compounds attenuates age-related cardiac remodeling.

Stéphanie Chacar, Joelle Hajal, Youakim Saliba, Patrick Bois, Nicolas Louka, Richard G Maroun, Jean-François Faivre, Nassim Fares

Open access · goldAbstract read
In one paragraph

Article in Aging cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Metabolic Changes in Cardiac Aging.Reviews in cardiovascular medicine · 2023
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Grapevine as a Rich Source of Polyphenolic Compounds.Molecules (Basel, Switzerland) · 2020
    Review
  11. Article
  12. Research progress on the role of CaMKII in heart disease.American journal of translational research · 2020
    Review
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Stéphanie ChacarFaculté de Médecine, Laboratoire de Recherche en Physiologie et Physiopathologie, LRPP, Pôle Technologie Santé, Université Saint Joseph, Beyrouth, Liban.
Joelle HajalFaculté de Médecine, Laboratoire de Recherche en Physiologie et Physiopathologie, LRPP, Pôle Technologie Santé, Université Saint Joseph, Beyrouth, Liban.
Youakim SalibaFaculté de Médecine, Laboratoire de Recherche en Physiologie et Physiopathologie, LRPP, Pôle Technologie Santé, Université Saint Joseph, Beyrouth, Liban.
Patrick BoisLaboratoire Signalisation et Transports Ioniques Membranaires (STIM), Université de Poitiers, Poitiers, France.
Nicolas LoukaFaculté des Sciences, Centre d'Analyses et de Recherche, UR GPF, Laboratoire CTA, Université Saint-Joseph, Beyrouth, Liban.
Richard G MarounFaculté des Sciences, Centre d'Analyses et de Recherche, UR GPF, Laboratoire CTA, Université Saint-Joseph, Beyrouth, Liban.
Jean-François FaivreLaboratoire Signalisation et Transports Ioniques Membranaires (STIM), Université de Poitiers, Poitiers, France.
Nassim FaresFaculté de Médecine, Laboratoire de Recherche en Physiologie et Physiopathologie, LRPP, Pôle Technologie Santé, Université Saint Joseph, Beyrouth, Liban.ORCID 0000-0002-2935-2611
Saint Joseph University · LBUniversité de Poitiers · FR

Funding

Saint Joseph University FM281Saint Joseph University FS93
6 · The paper itself

Abstract

With the onset of advanced age, cardiac-associated pathologies have increased in prevalence. The hallmarks of cardiac aging include cardiomyocyte senescence, fibroblast proliferation, inflammation, and hypertrophy. The imbalance between levels of reactive oxygen species (ROS) and antioxidant enzymes is greatly enhanced in aging cells, promoting cardiac remodeling. In this work, we studied the long-term impact of phenolic compounds (PC) on age-associated cardiac remodeling. Three-month-old Wistar rats were treated for 14 months till middle-age with either 2.5, 5, 10, or 20 mg kg

Indexed as

AgingModels, BiologicalAdministration, OralAnimalsApoptosisDietDose-Response Relationship, DrugEchocardiographyMaleOxidative StressPhenolsRatsRats, WistarReactive Oxygen SpeciesVentricular Dysfunction, LeftVentricular RemodelingPhenolsReactive Oxygen Speciesagingcardiac remodelingfibrosishypertrophyoxidative stressphenolic compounds

Identifiers

PMID30680911
PMCPMC6413651
OpenAlexW2911444592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.