Evidence map›Paper›PMID 30680861›Full record

ArticleAngewandte Chemie (International ed. in English)2019

Secondary-Ion Mass Spectrometry Images Cardiolipins and Phosphatidylethanolamines at the Subcellular Level.

Hua Tian, Louis J Sparvero, Paul Blenkinsopp, Andrew A Amoscato, Simon C Watkins, Hülya Bayır, Valerian E Kagan, Nicholas Winograd

Open access · greenAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 81 citations in OpenAlex.

  1. Article
  2. New Analytical Technologies to Resolve, Interpret, and Understand Lipid Complexity.Annual review of analytical chemistry (Palo Alto, Calif.) · 2026
    Review
  3. Review
  4. Article
  5. Mass Spectrometry Imaging.Analytical chemistry · 2025
    Review
  6. Article
  7. Review
  8. Article
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  10. Article
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  14. Article
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  19. Article
  20. Redox Pioneer: Professor Valerian Kagan.Antioxidants & redox signaling · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 4 countries.

Hua TianDepartment of Chemistry, Pennsylvania State University, 209 Chemistry Bldg., University Park, PA, 16802, USA.ORCID 0000-0002-3598-0219
Louis J SparveroDepartment of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, USA.ORCID 0000-0001-6347-8448
Paul BlenkinsoppIonoptika Ltd., Unit B6, Millbrook Cl, Chandler's Ford, Eastleigh, SO53 4BZ, UK.
Andrew A AmoscatoDepartment of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, USA.ORCID 0000-0002-1340-9150
Simon C WatkinsDepartment of Cell Biology, University of Pittsburgh, USA.ORCID 0000-0003-0825-0795
Hülya BayırDepartment of Chemistry, Pennsylvania State University, 209 Chemistry Bldg., University Park, PA, 16802, USA.ORCID 0000-0003-1174-3785
Valerian E KaganDepartment of Chemistry, Pennsylvania State University, 209 Chemistry Bldg., University Park, PA, 16802, USA.ORCID 0000-0002-7245-1885
Nicholas WinogradDepartment of Chemistry, Pennsylvania State University, 209 Chemistry Bldg., University Park, PA, 16802, USA.ORCID 0000-0002-2690-7714
Pennsylvania State University · USUniversity of Pittsburgh · USIonoptika (United Kingdom) · GB

Funding

Training and EducationU19AI068021 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GREENBERGER, JOEL S · 2005 to 2019
$44.4M
Regulation of Cardiolin Byosynthesis in Epithelial InjuryP01HL114453 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALLAMPALLI, RAMA K · 2014 to 2023
$21.3M
Mapping Lipid Oxidation in Traumatic Brain Injury by Mass Spectrometric ImagingR01NS076511 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Hülya Bayir, Valerian E Kagan · 2012 to 2026
$6.8M
Fluorescent Biosensors for Networks and PathwaysU54GM103529 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI WAGGONER, ALAN S. · 2012 to 2013
$6.3M
MOLECULAR IMAGING OF BIOMATERIALS - SINGLE CELLSR01EB002016 · NIBIB · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI WINOGRAD, NICHOLAS · 2003 to 2012
$4.1M
Oxidative Lipidomics in Pediatric Traumatic Brain InjuryR01NS061817 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAYIR, HÜLYA · 2008 to 2018
$3.3M
Oxidative Lipidomics in Pediatric Traumatic Brain InjuryR37NS061817 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Hülya Bayir · 2021 to 2026
$2.2M
Molecular Imaging of Biomaterials - Single CellsR01GM113746 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI WINOGRAD, NICHOLAS · 2014 to 2017
$1.7M
The molecular basis of cardiolipin-protein interactions implicated in intrinsic apoptosisR01GM113908 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAGAN, VALERIAN E · 2016 to 2019
$1.5M
NHLBI NIH HHS P01 HL114453NIAID NIH HHS U19 AI068021NIBIB NIH HHS R01 EB002016NIGMS NIH HHS R01 GM113746NIGMS NIH HHS R01 GM113908NIGMS NIH HHS U54 GM103529NINDS NIH HHS R01 NS061817NINDS NIH HHS R01 NS076511NINDS NIH HHS R37 NS061817
6 · The paper itself

Abstract

Millions of diverse molecules constituting the lipidome act as important signals within cells. Of these, cardiolipin (CL) and phosphatidylethanolamine (PE) participate in apoptosis and ferroptosis, respectively. Their subcellular distribution is largely unknown. Imaging mass spectrometry is capable of deciphering the spatial distribution of multiple lipids at subcellular levels. Here we report the development of a unique 70 keV gas-cluster ion beam that consists of (CO

Indexed as

Brain ChemistryAnimalsCardiolipinsCell LineHippocampusMiceNeuronsPhosphatidylethanolaminesRatsSpectrometry, Mass, Secondary IonCardiolipinsPhosphatidylethanolaminescardiolipinferroptosisgas-cluster ion beamsecondary-ion mass spectrometrysubcellular imaging

Identifiers

PMID30680861
PMCPMC6622167
OpenAlexW2914598164

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.