ArticleAmerican journal of physical anthropology2019
Craniofacial skeletal response to encephalization: How do we know what we think we know?
Article in American journal of physical anthropology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03025763 (Craniosynostosis Network), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Craniosynostosis Network
Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Maternal chronic wasting disease infection restricts fetal head size in white-tailed deer (Prion · 2026Article
- Calvarial Bloom Biomechanics: Dural Tension Governing Cranial Form.Clinical anatomy (New York, N.Y.) · 2026Review
- Spontaneous cephalic oscillations in vertebrate embryos support the Inside Story scenario of human development and evolution.Scientific reports · 2026Article
- Computational simulation of cranial soft tissue expansion on the cranium during early postnatal growth in humans.Journal of anatomy · 2026Article
- Current State of Knowledge Regarding the Treatment of Cranial Bone Defects: An Overview.Materials (Basel, Switzerland) · 2025Review
- Enhanced insights into the genetic architecture of 3D cranial vault shape using pleiotropy-informed GWAS.Communications biology · 2025Article
- Divergent patterns of cranial suture fusion in marsupial and placental mammals.Zoological journal of the Linnean Society · 2025Article
- A regulatory variant impacting TBX1 expression contributes to basicranial morphology in Homo sapiens.American journal of human genetics · 2024Article
- Article
- Postnatal growth and spatial conformity of the cranium, brain, eyeballs and masseter muscles in the macaque (Macaca mulatta).Journal of anatomy · 2023Article
- Evolutionary mechanisms modulating the mammalian skull development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- The genetic basis of neurocranial size and shape across varied lab mouse populations.Journal of anatomy · 2022Article
- Beyond the beak: Brain size and allometry in avian craniofacial evolution.Journal of anatomy · 2022Article
- Ontogenetic and in silico models of spatial-packing in the hypermuscular mouse skull.Journal of anatomy · 2021Article
- Abnormal cranium development in children and adolescents affected by syndromes or diseases associated with neurodysfunction.Scientific reports · 2021Observational
- The development and maintenance of sex differences in dietary breadth and complexity in Bornean orangutans.Behavioral ecology and sociobiology · 2021Article
- The Intertwined Evolution and Development of Sutures and Cranial Morphology.Frontiers in cell and developmental biology · 2021Review
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Dramatic changes in cranial capacity have characterized human evolution. Important evolutionary hypotheses, such as the spatial packing hypothesis, assert that increases in relative brain size (encephalization) have caused alterations to the modern human skull, resulting in a suite of traits unique among extant primates, including a domed cranial vault, highly flexed cranial base, and retracted facial skeleton. Most prior studies have used fossil or comparative primate data to establish correlations between brain size and cranial form, but the mechanistic basis for how changes in brain size impact the overall shape of the skull resulting in these cranial traits remains obscure and has only rarely been investigated critically. We argue that understanding how changes in human skull morphology could have resulted from increased encephalization requires the direct testing of hypotheses relating to interaction of embryonic development of the bones of the skull and the brain. Fossil and comparative primate data have thoroughly described the patterns of association between brain size and skull morphology. Here we suggest complementing such existing datasets with experiments focused on mechanisms responsible for producing the observed patterns to more thoroughly understand the role of encephalization in shaping the modern human skull.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.