Evidence map›Paper›PMID 30680609›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2019

Blockage of autophagic flux is associated with lymphocytosis and higher percentage of tumoral cells in chronic lymphocytic leukemia of B cells.

J-R Romero-Macías, R Pascual-Serra, O Roche, F Ruiz-Marcos, A Serrano-Martínez, P González-Aguado, B Belandia, M-J Ruiz-Hidalgo, R Sánchez-Prieto

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PubMed Publisher
In one paragraph

Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

J-R Romero-MacíasServicio de Hematología, Complejo Hospitalario Universitario de Albacete, 02006, Albacete, Spain.
R Pascual-SerraLaboratorio de Oncología Molecular, Unidad de Medicina Molecular, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, 02006, Albacete, Spain.
O RocheLaboratorio de Oncología Molecular, Unidad de Medicina Molecular, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, 02006, Albacete, Spain.
F Ruiz-MarcosServicio de Hematología, Complejo Hospitalario Universitario de Albacete, 02006, Albacete, Spain.
A Serrano-MartínezServicio de Hematología, Complejo Hospitalario Universitario de Albacete, 02006, Albacete, Spain.
P González-AguadoServicio de Hematología, Complejo Hospitalario Universitario de Albacete, 02006, Albacete, Spain.
B BelandiaLab. 1.5.2, Departamento de Biología del Cáncer, Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), Arturo Duperier, 4, 28029, Madrid, Spain.
M-J Ruiz-HidalgoLaboratorio de Oncología Molecular, Unidad de Medicina Molecular, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, 02006, Albacete, Spain.
R Sánchez-PrietoDepartamento de Ciencias Médicas, Facultad de Medicina, Universidad de Castilla-La Mancha, 02006, Albacete, Spain. rsprieto@iib.uam.es.ORCID http://orcid.org/0000-0003-0882-9780
Complejo Hospitalario Universitario de Albacete · ESUniversity of Castilla-La Mancha · ESInstituto de Investigaciones Biomédicas Sols-Morreale · ESMadrid Institute for Advanced Studies · ES

Funding

European Community Regional Development Funding ProgramMinisterio de Economía, Industria y Competitividad, Gobierno de España SAF2012-30862Ministerio de Economía, Industria y Competitividad, Gobierno de España SAF2015-64215R
6 · The paper itself

Abstract

purposeAutophagy has lately emerged as an important biological process with implications in several hematological pathologies. Recently, a growing body of evidence supports a putative role of autophagy in chronic lymphocytic leukemia; however, no definitive clue has been established so far. To elucidate this issue, we have developed a pilot study to measure autophagic flux in peripheral blood mononuclear cells from chronic lymphocytic leukemia patients, and explored its correlation with classical clinical/analytical parameters. METHODS/PATIENTS: Thirty-three chronic lymphocytic leukemia patients participated in the study. Autophagic flux in peripheral blood mononuclear cells was determined by western blot measuring the levels of the proteins p62 and lipidated LC3. Moreover, p62 mRNA levels were analyzed by RT-qPCR.

resultsLymphocytosis and the percentage of tumoral lymphocytes in chronic lymphocytic leukemia patients statistically correlate with a blocked autophagic flux.

conclusionAlterations in autophagic flux could play an important role in the physiopathology of chronic lymphocytic leukemia.

Indexed as

AutophagyAgedAged, 80 and overBiomarkers, TumorFemaleFollow-Up StudiesHumansLeukemia, Lymphocytic, Chronic, B-CellLeukocytes, MononuclearLymphocytosisMaleMiddle AgedPilot ProjectsPrognosisBiomarkers, TumorAutophagic fluxAutophagyChronic lymphocytic leukemiaLC3p62

Identifiers

PMID30680609
OpenAlexW2913730173

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.