Evidence map›Paper›PMID 30680546›Full record

ArticleJournal of cardiovascular translational research2019

Profound Increase of Lung Airway Resistance in Heart Failure: a Potential Important Contributor for Dyspnea.

Xiaohong Liu, Liuqing Yang, Dongmin Kwak, Lei Hou, Ruru Shang, Carolyn Meyer, Angela Panoskaltsis-Mortari, Xin Xu, Edward Kenneth Weir, Yingjie Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Xiaohong LiuShanxi Provincial People's Hospital, Taiyuan, China.
Liuqing YangCardiovascular Division and Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
Dongmin KwakCardiovascular Division and Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
Lei HouCardiovascular Division and Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
Ruru ShangShanxi Provincial People's Hospital, Taiyuan, China.
Carolyn MeyerDepartment of Medicine, University of Minnesota, Minneapolis, MN, USA.
Angela Panoskaltsis-MortariCardiovascular Division and Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
Xin XuDepartment of Exercise Rehabilitation, Shanghai University of Sport, Shanghai, 200438, China.
Edward Kenneth WeirDepartment of Medicine, University of Minnesota, Minneapolis, MN, USA.
Yingjie ChenCardiovascular Division and Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis, MN, 55455, USA. chenx106@umn.edu.ORCID 0000-0003-4545-5351
University of Minnesota · USShanxi Medical University · CNShanghai University of Sport · CN

Funding

Mechanisms of Treg and IL-35 in Regulating LV Failure-induced Lung Remodeling and Right Heart HypertrophyR01HL139797 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI CHEN, YINGJIE · 2018 to 2021
$2.2M
Molecular mechanism of 4E-binding proteins on heart failure developmentR01HL105406 · NHLBI · UNIVERSITY OF MINNESOTA · PI CHEN, YINGJIE · 2011 to 2014
$1.5M
NHLBI NIH HHS R01 HL105406NHLBI NIH HHS R01 HL139797
6 · The paper itself

Abstract

Dyspnea is a major symptom of heart failure (HF). Here, we have studied the lung remodeling and airway resistance in HF mice. We demonstrated that aortic banding-induced HF caused a dramatic decrease of lung compliance and an increase of lung airway resistance. The decrease of lung compliance was correlated with the increased lung weight in a linear fashion (γ

Indexed as

Airway RemodelingAirway ResistanceAnimalsDisease Models, AnimalDyspneaHeart FailureHumansLungMaleMice, Inbred BALB CMice, Inbred C57BLPulmonary FibrosisStroke VolumeTomography, X-Ray ComputedVentricular Function, LeftHeart failureLung complianceLung fibrosisPulmonary hypertension

Identifiers

PMID30680546
PMCPMC7339933
OpenAlexW2914230965

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.