Evidence map›Paper›PMID 30680517›Full record

ArticleJournal of assisted reproduction and genetics2019

The interaction effect of angiogenesis and endothelial dysfunction-related gene variants increases the susceptibility of recurrent pregnancy loss.

E A Trifonova, M G Swarovskaya, O A Ganzha, O V Voronkova, T V Gabidulina, V A Stepanov

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Balkan journal of medical genetics : BJMG · 2024
    Article
  5. Review
  6. Role ofInternational journal of reproductive biomedicine · 2022
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

E A TrifonovaResearch Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
M G SwarovskayaResearch Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. maria.swarovskaja@medgenetics.ru.ORCID http://orcid.org/0000-0002-5020-4971
O A GanzhaSiberian State Medical University, Tomsk, Russia.
O V VoronkovaSiberian State Medical University, Tomsk, Russia.
T V GabidulinaSiberian State Medical University, Tomsk, Russia.
V A StepanovResearch Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Russian Academy of Sciences · RUSiberian State Medical University · RU

Funding

Russian Foundation for Basic Research 18-44-700007
6 · The paper itself

Abstract

purposeThe role of genetic polymorphisms in the pathogenesis of recurrent pregnancy loss (RPL) has been studied intensively. Complex diseases, including miscarriage, are believed to have a polygenic basis, and gene-gene interactions can play a significant role in the etiology of the disease. This study was conducted to investigate the association of gene-gene interactions with angiogenesis, endothelial dysfunction-related gene polymorphisms, and RPL.

methodsA case-control study was conducted with 253 unrelated RPL patients with 2 or more spontaneous pregnancy losses and 339 healthy women with no history of pregnancy complications. Genotyping of single-nucleotide polymorphisms (SNPs) was performed using real-time polymerase chain reaction (real-time PCR), restriction fragment length polymorphism (RFLP), or allele-specific polymerase chain reaction methods.

resultsThe genotypes 677TT of the MTHFR gene, 936TT, 936CT, and 634CC, 634GC of the VEGF gene, and allele 894T of the NOS3 gene were associated with a predisposition to RPL in the Russian population. A significant role of additive and epistatic effects in the gene-gene interactions of the SNPs of SERPINE-1, ACE, NOS3, MTHFR, and VEGF genes in RPL was demonstrated.

conclusionsThe results showed that gene-gene interactions are important for RPL susceptibility. Additionally, analysis of the genotype combinations of several allelic variants provides more information on RPL risk than analysis of independent polymorphic markers.

Indexed as

Genetic Predisposition to DiseaseAbortion, SpontaneousAdultAllelesEpistasis, GeneticFemaleGenetic Association StudiesGenotypeHumansMethylenetetrahydrofolate Reductase (NADPH2)Nitric Oxide Synthase Type IIIPolymorphism, Restriction Fragment LengthPolymorphism, Single NucleotidePregnancyRisk FactorsThrombophiliaMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanNitric Oxide Synthase Type IIINOS3 protein, humanVascular Endothelial Growth Factor AVEGFA protein, humanEndothelial dysfunctionGene–gene interactionsRecurrent miscarriageSingle-nucleotide polymorphism

Identifiers

PMID30680517
PMCPMC6505001
OpenAlexW2912533764

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.