ArticleWorld journal of surgery2019
Does Primary Hyperparathyroidism Have an Association with Thyroid Papillary Cancer? A Retrospective Cohort Study.
Article in World journal of surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Risk of Malignant Neoplasm in Patients with Primary Hyperparathyroidism: A Systematic Review and Meta-analysis.Calcified tissue international · 2024Pooled it
- Surgical management of ectopic mediastinal parathyroid adenomas: a report of three cases highlighting diagnostic and operative challenges.Journal of cardiothoracic surgery · 2025Article
- The Nexus of Hyperparathyroidism and Thyroid Carcinoma: Insights into Pathogenesis and Diagnostic Challenges-A Narrative Review.Journal of clinical medicine · 2023Review
- Clinical characteristics of primary parathyroid adenoma and its relationship with coexisting papillary thyroid carcinoma: a clinical retrospective study.Gland surgery · 2023Article
- Primary Hyperparathyroidism with Thyroid Cancer: Clinicopathologic Features.Sisli Etfal Hastanesi tip bulteni · 2022Article
- Changes in clinical patterns of Chinese patients with primary hyperparathyroidism in the past 12 years: a single-center experience.Endocrine connections · 2021Article
- Increased thyroid malignancy in patients with primary hyperparathyroidism.Endocrine connections · 2021Article
- Differences in Clinicopathological Characteristics of Papillary Thyroid Carcinoma between Symptomatic and Asymptomatic Patients with Primary Hyperparathyroidism.International journal of endocrinology · 2021Article
- Association of Hyperparathyroidism and Papillary Thyroid Cancer: A Multicenter Retrospective Study.Endocrinology and metabolism (Seoul, Korea) · 2020Article
- Complex management decisions in a woman with concurrent primary hyperparathyroidism and metastatic papillary thyroid carcinoma, both presenting during pregnancy.Endocrinology, diabetes & metabolism case reports · 2019Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate the relationship between primary hyperparathyroidism (pHPT) and papillary thyroid cancer (PTC).
methodsThe perioperative findings of 275 patients with pHPT who underwent surgery between January 2014 and December 2017 were retrospectively reviewed. Thirty-one patients were diagnosed with pHPT and PTC concurrently. Pathology results and demographic findings of these patients were compared with 186 patients who underwent thyroidectomy and diagnosed with PTC at the same time interval.
resultsThe co-occurrence of pHPT and PTC was 11.3% (31/275). The median ages of the pHPT, pHPT + PTC, and PTC groups were 55, 57, and 50 years old, respectively (p < 0.001). The diameter of tumor was smaller in the pHPT + PTC group [median 7 mm (range 0.5-25 mm) vs. 15 mm (range 1-100 mm)], with higher rates of microcarcinomas (p < 0.001), than the patients in the PTC group. Examination of tumor morphology showed higher rates of tumor capsule invasion and multicentricity in the pHPT + PTC group than those in the isolated PTC group (p = 0.02, p = 0.04, respectively).
conclusionThe pHPT + PTC group had significantly smaller tumor diameter than the PTC group. This result may support the idea that pHPT leads to overdiagnosis of PTC. However, observation of high rates of tumor capsule invasion and multicentricity in the pHPT + PTC group may suggest an associative etiology with more aggressive PTC.
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