ArticleSports medicine - open2019
A Novel Ingestion Strategy for Sodium Bicarbonate Supplementation in a Delayed-Release Form: a Randomised Crossover Study in Trained Males.
Article in Sports medicine - open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Gastrointestinal Symptoms Associated With Sodium Bicarbonate Supplementation Protocols: A Systematic Review.European journal of sport science · 2026Pooled it
- Effects of Sodium Bicarbonate Supplementation on Muscular Strength and Endurance: A Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2020Pooled it
- Bicarbonate and Carbohydrate Co-Ingestion During Exercise in a Novel Gel Format Improves Time-Trial Performance After 3 h of Moderate-Intensity Exercise in Trained Cyclists.Scandinavian journal of medicine & science in sports · 2026Trial
- Trial
- Effects of acute and multi-day low-dose sodium bicarbonate intake on high-intensity endurance exercise performance in male recreational cyclists.European journal of applied physiology · 2024Trial
- Effects of Enteric-Coated Formulation of Sodium Bicarbonate on Bicarbonate Absorption and Gastrointestinal Discomfort.Nutrients · 2024Trial
- Does varying the ingestion period of sodium citrate influence blood alkalosis and gastrointestinal symptoms?PloS one · 2021Trial
- Sodium citrate ingestion protocol impacts induced alkalosis, gastrointestinal symptoms, and palatability.Physiological reports · 2019Trial
- Common questions and misconceptions of sodium bicarbonate as an ergogenic aid: what does the science really show?Journal of the International Society of Sports Nutrition · 2026Review
- Prevalence, implementation, and barriers of sodium bicarbonate supplementation in team sports.Biology of sport · 2026Article
- From Science to Dressing Room: Dietary Supplements for Elite Soccer Performance.Journal of functional morphology and kinesiology · 2025Review
- Nutritional Strategies to Improve Post-exercise Recovery and Subsequent Exercise Performance: A Narrative Review.Sports medicine (Auckland, N.Z.) · 2025Review
- The Effects of a Carbohydrate Hydrogel System for the Delivery of Bicarbonate Mini-Tablets on Acid-Base Buffering and Gastrointestinal Symptoms in Resting Well-trained Male Cyclists.Sports medicine - open · 2024Article
- Use of Buffers in Specific Contexts: Highly Trained Female Athletes, Extreme Environments and Combined Buffering Agents-A Narrative Review.Sports medicine (Auckland, N.Z.) · 2023Review
- Effects of serial and acute enteric-coated sodium bicarbonate supplementation on anaerobic performance, physiological profile, and metabolomics in healthy young men.Frontiers in nutrition · 2022Article
- Connections between Different Sports and Ergogenic Aids-Focusing on Salivary Cortisol and Amylase.Medicina (Kaunas, Lithuania) · 2021Review
- Capsule Size Alters the Timing of Metabolic Alkalosis Following Sodium Bicarbonate Supplementation.Frontiers in nutrition · 2021Article
- Sodium Bicarbonate Ingestion Improves Time-to-Exhaustion Cycling Performance and Alters Estimated Energy System Contribution: A Dose-Response Investigation.Frontiers in nutrition · 2020Article
- The Impact of Individualizing Sodium Bicarbonate Supplementation Strategies on World-Class Rowing Performance.Frontiers in nutrition · 2020Article
- Post-exercise Supplementation of Sodium Bicarbonate Improves Acid Base Balance Recovery and Subsequent High-Intensity Boxing Specific Performance.Frontiers in nutrition · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSodium bicarbonate (NaHCO
methodsIn a randomised crossover design, pharmacokinetic responses and acid-base status were compared following two forms of NaHCO
resultsIncidences of GI symptoms and overall severity were significantly lower (mean difference = 45.1%, P < 0.0005 and 47.5%, P < 0.0005 for incidences and severity, respectively) with the CAP than with the SOL. Symptoms displayed increases at 40 to 80 min post-ingestion with the SOL that were negated with CAP (P < 0.05). Time to reach peak bicarbonate concentration, pH and BE were significantly longer with CAP than with the SOL.
conclusionsIn summary, CAP can mitigate GI symptoms induced with SOL and should be ingested earlier to induce similar acid-base changes. Furthermore, CAP may be more ergogenic in those who experience severe GI distress with SOL, although this warrants further investigation.
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