Evidence map›Paper›PMID 30680453›Full record

ArticleVirchows Archiv : an international journal of pathology2019

AL amyloidosis with a localized B cell neoplasia.

Christiane Stuhlmann-Laeisz, Stefan O Schönland, Ute Hegenbart, Ilske Oschlies, Julius-Valentin Baumgart, Sandra Krüger, Christoph Röcken

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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. [Diagnosis of Amyloidosis in Hand and Plastic Surgery Patients: Optimal Tissue Selection and Examination Methods for Early Detection].Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V... · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Christiane Stuhlmann-LaeiszDepartment of Pathology, Christian-Albrechts-University Kiel, Arnold-Heller-Str. 3/14, D-24105, Kiel, Germany.
Stefan O SchönlandMedical Department V, Amyloidosis Center, University of Heidelberg, Heidelberg, Germany.
Ute HegenbartMedical Department V, Amyloidosis Center, University of Heidelberg, Heidelberg, Germany.
Ilske OschliesDepartment of Pathology, Christian-Albrechts-University Kiel, Arnold-Heller-Str. 3/14, D-24105, Kiel, Germany.
Julius-Valentin BaumgartDepartment of Pathology, Christian-Albrechts-University Kiel, Arnold-Heller-Str. 3/14, D-24105, Kiel, Germany.
Sandra KrügerDepartment of Pathology, Christian-Albrechts-University Kiel, Arnold-Heller-Str. 3/14, D-24105, Kiel, Germany.
Christoph RöckenDepartment of Pathology, Christian-Albrechts-University Kiel, Arnold-Heller-Str. 3/14, D-24105, Kiel, Germany. christoph.roecken@uksh.de.ORCID http://orcid.org/0000-0002-6989-8002
Christian-Albrechts-Universität zu Kiel · DEHeidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunoglobulin light chain-derived (AL) amyloidosis may occur as a systemic disease usually with dismal prognosis and a localized variant with favorable outcome. We report 29 patients with AL amyloidosis and associated lymphoplasmacytic infiltrate spatially related to amyloid deposits. In 17 cases, the amyloid deposits were classified as ALλ and 12 as ALκ Histopathology in all cases showed relatively sparse plasma cells and B cells without tumor or sheet formation by the lymphoplasmacytic infiltrate. The B cells predominantly showed an immunophenotype of the marginal zone. In situ, hybridization revealed 17 cases with λ- and 10 with κ light chain restricted plasma cells, which was concordant with the AL subtype in each case. Clonal immunoglobulin heavy variable gene (IGHV) or κ light chain rearrangement was found in 23/29 interpretable cases. A single case harbored a MYD88

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorB-LymphocytesDNA Mutational AnalysisFemaleGene Rearrangement, B-Lymphocyte, Heavy ChainGene Rearrangement, B-Lymphocyte, Light ChainHumansImmunoglobulin Heavy ChainsImmunoglobulin kappa-ChainsImmunoglobulin lambda-ChainsImmunoglobulin Light-chain AmyloidosisImmunohistochemistryLymphoma, B-CellBiomarkers, TumorImmunoglobulin Heavy ChainsImmunoglobulin kappa-ChainsImmunoglobulin lambda-ChainsMYD88 protein, humanMyeloid Differentiation Factor 88AmyloidB cell lymphomaCongo redLight chain

Identifiers

PMID30680453
OpenAlexW2911857361

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.