Evidence map›Paper›PMID 30680451›Full record

SynthesisInternational journal of colorectal disease2019

Impact of the preoperative prognostic nutritional index on postoperative and survival outcomes in colorectal cancer patients who underwent primary tumor resection: a systematic review and meta-analysis.

Guangwei Sun, Yalun Li, Yangjie Peng, Dapeng Lu, Fuqiang Zhang, Xueyang Cui, Qingyue Zhang, Zhuang Li

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in International journal of colorectal disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 11 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Article
  13. Article
  14. Article
  15. Predicting intestinal ischemia in mechanical intestinal obstruction: the role of the C-reactive protein-albumin-lymphocyte index.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026
    Article
  16. Article
  17. Increased Infiltration of CD4Cancer reports (Hoboken, N.J.) · 2026
    Observational
  18. Article
  19. Article
  20. Observational

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Guangwei SunDepartment of Anorectal Surgery, The First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.
Yalun LiDepartment of Anorectal Surgery, The First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.
Yangjie PengDepartment of Anorectal Surgery, The First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.
Dapeng LuDepartment of Anorectal Surgery, The First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.
Fuqiang ZhangDepartment of Anorectal Surgery, The First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.
Xueyang CuiDepartment of Anorectal Surgery, The First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.
Qingyue ZhangDepartment of Anorectal Surgery, The First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.
Zhuang LiDepartment of Anorectal Surgery, The First Hospital of China Medical University, Shenyang, 110001, People's Republic of China. cmu1stbill@163.com.ORCID http://orcid.org/0000-0001-9056-7681

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe aimed to explore whether the preoperative prognostic nutritional index (PNI) could be an indicator of prognostic outcomes in colorectal cancer (CRC) patients.

methodsA systematic review and meta-analysis was conducted using the PubMed, Embase, and Web of Science databases. All original comparative studies published in English that were related to a high PNI versus a low PNI in CRC patients were included.

resultsA total of 10 studies involving 6372 patients were included in our meta-analysis. Our overall analysis indicated that the low-PNI group had a significantly reduced overall survival (OS) (HR = 1.87, 95% CI = 1.45-2.42, P < 0.01), cancer-specific survival (HR = 1.53, 95% CI = 1.07-2.19, P = 0.02), and disease-free survival (HR = 1.67, 95% CI = 1.23-2.26, P < 0.01) compared with the high-PNI group. Furthermore, our subgroup results indicated that a high PNI could be a significant indicator of improved OS in TNM stage II (HR = 1.93, 95% CI = 1.29-2.90, P < 0.01) and III (HR = 1.71, 95% CI = 1.25-2.34, P < 0.01), and a similar trend in TNM stage I or IV could also be observed though without statistical significance. Regarding postoperative complications, our pooled results indicated that the low-PNI group had a significantly increased incidence of total and severe postoperative complications.

conclusionsOur findings indicated that CRC patients with a preoperative high PNI had a significantly improved OS. However, almost only Asian CRC patients were included based on current issue.

Indexed as

Nutrition AssessmentPreoperative CareAgedColorectal NeoplasmsFemaleHumansMaleMiddle AgedNeoplasm StagingPostoperative ComplicationsPostoperative PeriodPrognosisSurvival AnalysisColorectal cancerComplicationsMeta-analysisOverall survivalPrognostic nutritional index

Identifiers

PMID30680451

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.