ArticleBioengineering & translational medicine2019
Engineering, on-demand manufacturing, and scaling-up of polymeric nanocapsules.
Article in Bioengineering & translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Innovative Strategies of Nanocapsules for Maximizing Efficacy in Tumor Immunotherapy.International journal of nanomedicine · 2026Review
- Chondroitin Sulfate-Based Nanocapsules as Nanocarriers for Drugs and Nutraceutical Supplements.International journal of molecular sciences · 2024Article
- Controlling the protein corona of polymeric nanocapsules: effect of polymer shell on protein adsorption.Drug delivery and translational research · 2024Article
- Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumors.Frontiers in immunology · 2023Article
- Dextran Nanocapsules withPharmaceutics · 2022Article
- Quantification of the actual composition of polymeric nanocapsules: a quality control analysis.Drug delivery and translational research · 2022Article
- The Importance of Nanocarrier Design and Composition for an Efficient Nanoparticle-Mediated Transdermal Vaccination.Vaccines · 2021Review
- Diflunisal Targeted Delivery Systems: A Review.Materials (Basel, Switzerland) · 2021Review
- Microencapsulated Chitosan-Based Nanocapsules: A New Platform for Pulmonary Gene Delivery.Pharmaceutics · 2021Article
- Design of Chitosan Nanocapsules with Compritol 888 ATO® for Imiquimod Transdermal Administration. Evaluation of Their Skin Absorption by Raman Microscopy.Pharmaceutical research · 2020Article
- Article
- Design of Polymeric Nanocapsules for Intranasal Vaccination against Mycobacterium Tuberculosis: Influence of the Polymeric Shell and Antigen Positioning.Pharmaceutics · 2020Article
- Hyaluronic Acid Nanocapsules as a Platform for Needle-Free Vaccination.Pharmaceutics · 2019Article
- Engineering, on-demand manufacturing, and scaling-up of polymeric nanocapsules.Bioengineering & translational medicine · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polymeric nanocapsules are versatile delivery systems with the capacity to load lipophilic drugs in their oily nucleus and hydrophilic drugs in their polymeric shell. The objective of this work was to expand the technological possibilities to prepare customized nanocapsules. First, we adapted the solvent displacement technique to modulate the particle size of the resulting nanocapsules in the 50-500 nm range. We also produced nanosystems with a shell made of one or multiple polymer layers i.e. chitosan, dextran sulphate, hyaluronate, chondroitin sulphate, and alginate. In addition, we identified the conditions to translate the process into a miniaturized high-throughput tailor-made fabrication that enables massive screening of formulations. Finally, the production of the nanocapsules was scaled-up both in a batch production, and also using microfluidics. The versatility of the properties of these nanocapsules and their fabrication technologies is expected to propel their advance from bench to clinic.
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