ArticleBioengineering & translational medicine2019
Uptake and function of membrane-destabilizing cationic nanogels for intracellular drug delivery.
Article in Bioengineering & translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
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- Chlorpromazine-Polypyrrole Drug Delivery System Tailored for Neurological Application.Molecules (Basel, Switzerland) · 2024Article
- siRNA Delivery from Cationic Nanocarriers Prepared by Diffusion-assisted Loading in the Presence and Absence of Electrostatic Interactions.Journal of applied polymer science · 2024Article
- Tuning the pH-Responsive Properties of (2-Diisopropylamino) Ethyl Methacrylate-Based Cationic Nanoparticles: Toward Enhanced Nanoparticle Stability and Cytocompatibility.Biomedical materials & devices (New York, N.Y.) · 2024Article
- Multifunctional Polymeric Nanogels for Biomedical Applications.Gels (Basel, Switzerland) · 2021Review
- Purification and erythrocyte-membrane perturbing activity of a ketose-specific lectin fromBiotechnology reports (Amsterdam, Netherlands) · 2021Article
- Peptide conjugation enhances the cellular co-localization, but not endosomal escape, of modular poly(acrylamide-co-methacrylic acid) nanogels.Journal of controlled release : official journal of the Controlled Release Society · 2021Article
- Article
- QCM-D assay for quantifying the swelling, biodegradation, and protein adsorption of intelligent nanogels.Journal of applied polymer science · 2020Article
- Hydrogels in the clinic.Bioengineering & translational medicine · 2020Review
- Smart Nanoformulation Based on Stimuli-Responsive Nanogels and Curcumin: Promising Therapy against Colon Cancer.ACS omega · 2020Article
- Synthetic networks with tunable responsiveness, biodegradation, and molecular recognition for precision medicine applications.Science advances · 2019Article
- Cytoplasmic delivery of functional siRNA using pH-Responsive nanoscale hydrogels.International journal of pharmaceutics · 2019Article
- Uptake and function of membrane-destabilizing cationic nanogels for intracellular drug delivery.Bioengineering & translational medicine · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The design of intracellular drug delivery vehicles demands an in-depth understanding of their internalization and function upon entering the cell to tailor the physicochemical characteristics of these platforms and achieve efficacious treatments. Polymeric cationic systems have been broadly accepted to be membrane disruptive thus being beneficial for drug delivery inside the cell. However, if excessive destabilization takes place, it can lead to adverse effects. One of the strategies used to modulate the cationic charge is the incorporation of hydrophobic moieties, thus increasing the hydrophobic content. We have demonstrated the successful synthesis of nanogels based on diethylaminoethyl methacrylate and poly(ethylene glycol) methyl ether methacrylate. Addition of the hydrophobic monomers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.