Evidence map›Paper›PMID 30680310›Full record

ArticleeNeuro

Isoflurane Inhibits Dopaminergic Synaptic Vesicle Exocytosis Coupled to Ca

Christina L Torturo, Zhen-Yu Zhou, Timothy A Ryan, Hugh C Hemmings

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Synapse-Specific Trapping of SNARE Machinery Proteins in the AnesthetizedThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Christina L TorturoDepartment of Anesthesiology, Weill Cornell Medicine, New York, NY 10065.
Zhen-Yu ZhouDepartment of Anesthesiology, Weill Cornell Medicine, New York, NY 10065.ORCID 0000-0002-5024-5263
Timothy A RyanDepartment of Anesthesiology, Weill Cornell Medicine, New York, NY 10065.ORCID 0000-0003-2533-9548
Hugh C HemmingsDepartment of Anesthesiology, Weill Cornell Medicine, New York, NY 10065.ORCID 0000-0002-6043-5482
Cornell University · US

Funding

SYNAPTIC MECHANISMS OF GENERAL ANESTHETIC ACTIONR01GM058055 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HEMMINGS, HUGH C · 1998 to 2023
$10.1M
NIGMS NIH HHS R01 GM058055
6 · The paper itself

Abstract

Volatile anesthetics affect neuronal signaling by poorly understood mechanisms. Activation of central dopaminergic pathways has been implicated in emergence from general anesthesia. The volatile anesthetic isoflurane differentially inhibits glutamatergic and GABAergic synaptic vesicle (SV) exocytosis by reducing presynaptic Ca

Indexed as

Anesthetics, InhalationAnimalsCalciumCalcium Channels, N-TypeCells, CulturedDopamineExocytosisFemaleIsofluraneMaleNeuronsRats, Sprague-DawleySynaptic TransmissionSynaptic VesiclesVentral Tegmental AreaAnesthetics, InhalationCacna1b protein, ratCalciumCalcium Channels, N-TypeDopamineIsofluraneanesthesiacalciumdopamineexocytosisneuropharmacologysynaptic transmission

Identifiers

PMID30680310
PMCPMC6345200
OpenAlexW2908643180

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.