Evidence map›Paper›PMID 30680244›Full record

ArticleCentral European journal of urology2018

Impact of leukocytospermia on sperm dynamic motility parameters, DNA and chromosomal integrity.

Alaa Moubasher, Heba Sayed, Eman Mosaad, Ahmed Mahmoud, Fawzy Farag, Emad A Taha

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Central European journal of urology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Role of Infection and Leukocytes in Male Infertility.Advances in experimental medicine and biology · 2022
    Article
  11. Article
  12. Sperm DNA Fragmentation: A New Guideline for Clinicians.The world journal of men's health · 2020
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alaa MoubasherDepartment of Dermatology, Venereology and Andrology, Faculty of Medicine, Assiut University, Egypt.
Heba SayedDepartment of Dermatology, Venereology and Andrology, Faculty of Medicine, Assiut University, Egypt.
Eman MosaadDepartment of Clinical Pathology - South Egypt Cancer Institute, Assiut University, Egypt.
Ahmed MahmoudDepartment of Endocrinology and Andrology, Ghent University Hospital, Ghent, Belgium.
Fawzy FaragDepartment of Urology, Sohag University Hospital, Egypt.
Emad A TahaDepartment of Dermatology, Venereology and Andrology, Faculty of Medicine, Assiut University, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTo characterize sperm dynamic motility patterns and chromatin integrity in infertile men with leukocytospermia. MATERIAL AND

methodsFifty patients with primary infertility and oligoasthenoteratozoospermia included in this prospective, controlled, blind study. All patients underwent clinical evaluation, semen peroxidase stain, computer aided semen analysis (CASA), sperm DNA integrity evaluation with acridine orange test (AOT) and fluorescence in situ hybridization (FISH) analysis of 18, X and Y chromosomes. Pregnancy outcomes were documented following antibiotic treatment of patients with leukocytospermia.

resultsInfertile men with leukocytospermia had significantly lower progressive and total sperm motility percentages compared to the control group. Sperm dynamic motility parameters by CASA including curvilinear, straight line and average pathway velocities, straightness and amplitude of lateral head displacement were significantly lower in leukocytospermia. Sperm DNA fragmentation index was significantly higher in leukocytospermia. Percentages of sperm with disomy XY and 18 were significantly higher. These changes in sperm motility parameters and DNA integrity correlated with the number of peroxidase positive leukocytes. Follow-up of 23 of the 25 patients with leukocytospermia after antibiotic treatment revealed significantly higher pregnancy rates in cured patients than in those with persistent leukocytospermia.

conclusionsLeukocytospermia has a significant impact on sperm dynamic motility patterns, DNA and chromosomal integrity in infertile men which can adversely affect the likelihood of a successful pregnancy.

Indexed as

computer aided semen analysisFISHleukocytospermiasperm DNA

Identifiers

PMID30680244
PMCPMC6338814

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.