ArticleEye (London, England)2019
Changes in macular drusen parameters preceding the development of neovascular age-related macular degeneration.
Article in Eye (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Retinal Pigment Epithelium Curvature Can Predict Late Age-Related Macular Degeneration.Investigative ophthalmology & visual science · 2024Article
- Early Optical Coherence Tomography Biomarkers for Selected Retinal Diseases-A Review.Diagnostics (Basel, Switzerland) · 2023Review
- Multispectral pattern recognition measures change in drusen area in age-related macular degeneration with high congruency to expert graders.Scientific reports · 2022Article
- Potential Therapeutic Benefit of NADNutrients · 2020Review
- To Peel or Not to Peel: Pars Plana Vitrectomy with Macular Membrane Peel in Eyes with Abnormalities of Vitreomacular Interface and Coexisting Dry Age-Related Macular Degeneration.Clinical ophthalmology (Auckland, N.Z.) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess the rate of change in macular drusen load in fellow eyes of patients with unilateral neovascular age-related macular degeneration (AMD) to evaluate whether the change in drusen load determines the onset and type of choroidal neovascularisation (CNV).
methodsSubjects with unilateral neovascular AMD with a minimum of 2 years follow-up were identified retrospectively from the hospital electronic database. Drusen count, area and volume measurements at the macula of the contralateral eye were recorded using the commercial software on the Topcon 3D OCT-2000 devices over the previous 2 years. The mean rate of change of these parameters over time was compared between fellow eyes that converted to various CNV subtypes and those that did not.
resultsTwo hundred forty-eight patients met the inclusion criteria. Of these patients, 179 patients did not progress to neovascular AMD (Group 1) while 69 patients converted (Group 2) at the end of 2 years follow up. Mean drusen volumes and drusen areas increased significantly in Group 2 in the 2nd year by 0.031 mm
conclusionA significant increase in mean drusen volume occurs in eyes in the preceding 12 months prior to conversion to neovascular AMD and this change is more significant in eyes with occult CNV.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.