SynthesisEuropean journal of human genetics : EJHG2019
Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits.
Abstract readMeta-Analysis
In one paragraph
Synthesis in European journal of human genetics : EJHG, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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25citing papers in PubMed, 1 pooled it
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A large genome-wide association study of QT interval length utilizing electronic health records.Genetics · 2022Pooled it
- Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization: A Mendelian Randomization Study in the UK Biobank.Circulation. Genomic and precision medicine · 2021Trial
- Genome-wide association study-identified novel genetic loci for QT interval in Taiwan: implications for population-specific arrhythmia risk.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Article
- Genetics of supraventricular tachycardia: current evidence with a focus on translational relevance and personalized medicine.Frontiers in cardiovascular medicine · 2026Review
- Artificial Intelligence and ECG: A New Frontier in Cardiac Diagnostics and Prevention.Biomedicines · 2025Review
- Precision cardiovascular medicine: shifting the innovation paradigm.Frontiers in science · 2025Article
- Advancing drug development for atrial fibrillation by prioritising findings from human genetic association studies.EBioMedicine · 2024Article
- Phenotypic and Genetic Factors Associated with Absence of Cardiomyopathy Symptoms in PLN:c.40_42delAGA Carriers.Journal of cardiovascular translational research · 2023Article
- Genome-wide association studies: utility and limitations for research in physiology.The Journal of physiology · 2023Article
- Cross-modal autoencoder framework learns holistic representations of cardiovascular state.Nature communications · 2023Article
- Global chromatin landscapes identify candidate noncoding modifiers of cardiac rhythm.The Journal of clinical investigation · 2023Article
- Heart-Type Fatty Acid Binding Protein, Cardiovascular Outcomes, and Death: Findings From the German CKD Cohort Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022Article
- The genetic case for cardiorespiratory fitness as a clinical vital sign and the routine prescription of physical activity in healthcare.Genome medicine · 2021Article
- HAND transcription factors cooperatively specify the aorta and pulmonary trunk.Developmental biology · 2021Article
- HeterozygousGenes · 2021Article
- Semi-Lethal Primary Ciliary Dyskinesia in Rats Lacking theInternational journal of molecular sciences · 2021Article
- Discovering and Visualizing Disease-Specific Electrocardiogram Features Using Deep Learning: Proof-of-Concept in Phospholamban Gene Mutation Carriers.Circulation. Arrhythmia and electrophysiology · 2021Article
- Development of the Cardiac Conduction System.Cold Spring Harbor perspectives in biology · 2020Review
- Article
- Genetic Variation in Cardiometabolic Traits and Medication Targets and the Risk of Hypertensive Disorders of Pregnancy.Circulation · 2020Article
Corrections and comments
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Authors and funding
61 authors.
Jessica van SettenDivision Heart & Lungs, Department of Cardiology, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands. J.vanSetten@umcutrecht.nl.ORCID 0000-0002-4934-7510
Niek VerweijDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0002-4303-7685
Hamdi MbarekDepartment of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-1108-0371
Maartje N NiemeijerDepartment of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
Stella TrompetDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Dan E ArkingMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Ilaria GandinResearch Unit, AREA Science Park, Trieste, Italy.
Niels GrarupThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-5526-1070
Leanne M HallDepartment of Cardiovascular Sciences, University of Leicester, Leicester, England.
Daiane HemerichDivision Heart & Lungs, Department of Cardiology, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, 33520, Tampere, Finland.
Hao MeiCenter of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
Martina Müller-NurasyidInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.ORCID 0000-0003-3793-5910
Bram P PrinsHuman Genetics Research Centre, ICCS, St George's University of London, London, UK.
Antonietta RobinoInstitute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.
Albert V SmithIcelandic Heart Association, Kopavogur, Iceland.
Helen R WarrenWilliam Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK.
Folkert W AsselbergsDivision Heart & Lungs, Department of Cardiology, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.ORCID 0000-0002-1692-8669
Dorret I BoomsmaDepartment of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Mark J CaulfieldWilliam Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK.
Mark EijgelsheimDepartment of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
Ian FordRobertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.
Torben HansenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Tamara B HarrisLaboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, MD, USA.
Susan R HeckbertCardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA.
Jouke-Jan HottengaDepartment of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Annamaria IorioCardiovascular Department, "Ospedali Riuniti and University of Trieste", Trieste, Italy.
Jan A KorsDepartment of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.
Allan LinnebergCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital-The Capital Region, Copenhagen, Denmark.ORCID 0000-0002-0994-0184
Peter W MacFarlaneInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Thomas MeitingerDZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Christopher P NelsonDepartment of Cardiovascular Sciences, University of Leicester, Leicester, England.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, and Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 20520, Finland.
Claudia T Silva AldanaGenetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID 0000-0001-8172-5860
Gianfranco SinagraCardiovascular Department, "Ospedali Riuniti and University of Trieste", Trieste, Italy.
Moritz SinnerDepartment of Medicine I, Ludwig-Maximilians-Universität, Munich, Germany.
Elsayed Z SolimanEpidemiological Cardiology Research Center (EPICARE), Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Monika StollCARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands.
Andre UitterlindenDepartment of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
Cornelia M van DuijnGenetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Melanie WaldenbergerDZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Alvaro AlonsoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.ORCID 0000-0002-2225-8323
Paolo GaspariniDSM, University of Trieste, Trieste, Italy.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.
Yalda JamshidiHuman Genetics Research Centre, ICCS, St George's University of London, London, UK.ORCID 0000-0003-0151-6482
Stefan KääbDepartment of Medicine I, Ludwig-Maximilians-Universität, Munich, Germany.
Jørgen K KantersLaboratory of Experimental Cardiology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-3267-4910
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, 33520, Tampere, Finland.
Patricia B MunroeWilliam Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK.
Annette PetersDZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, Leicester, England.
Nona SotoodehniaCardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, WA, USA.
Sheila UliviInstitute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
Eco J C de GeusDepartment of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-6022-2666
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-3246-8359
Bruno StrickerDepartment of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
Pim van der HarstDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0002-2713-686X
Paul I W de BakkerDepartment of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.
Aaron IsaacsCARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands. a.isaacs@maastrichtuniversity.nl.ORCID 0000-0001-5037-4834
Funding
Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI HALL, JOHN E · 2016 to 2025
$38.2MBritish Heart Foundation PG/12/38/29615NIGMS NIH HHS U54 GM115428
Abstract
Genome-wide association studies (GWAS) of quantitative electrocardiographic (ECG) traits in large consortia have identified more than 130 loci associated with QT interval, QRS duration, PR interval, and heart rate (RR interval). In the current study, we meta-analyzed genome-wide association results from 30,000 mostly Dutch samples on four ECG traits: PR interval, QRS duration, QT interval, and RR interval. SNP genotype data was imputed using the Genome of the Netherlands reference panel encompassing 19 million SNPs, including millions of rare SNPs (minor allele frequency < 5%). In addition to many known loci, we identified seven novel locus-trait associations: KCND3, NR3C1, and PLN for PR interval, KCNE1, SGIP1, and NFKB1 for QT interval, and ATP2A2 for QRS duration, of which six were successfully replicated. At these seven loci, we performed conditional analyses and annotated significant SNPs (in exons and regulatory regions), demonstrating involvement of cardiac-related pathways and regulation of nearby genes.
Indexed as
ElectrocardiographyGenetic LociPolymorphism, Single NucleotideFemaleGenome-Wide Association StudyHumansMaleNetherlands
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