Evidence map›Paper›PMID 30679808›Full record

ReviewNature reviews. Immunology2019

Adaptive immune responses to primary and secondary dengue virus infections.

Ashley L St John, Abhay P S Rathore

Open access · bronzeAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 174 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
174citing papers in PubMed, 5 pooled it
33.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

174 citing papers in PubMed, 5 syntheses or guidelines pooled it, 322 citations in OpenAlex.

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  16. Contribution of Immune Responses toJournal of inflammation research · 2026
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114 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Ashley L St JohnProgram in Emerging Infectious Diseases, Duke-National University of Singapore, Singapore, Singapore. ashley.st.john@duke-nus.edu.sg.ORCID http://orcid.org/0000-0001-5098-1044
Abhay P S RathoreDepartment of Pathology, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0003-2039-2964
Duke Medical Center · USNational University of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dengue is the leading mosquito-borne viral illness infecting humans. Owing to the circulation of multiple serotypes, global expansion of the disease and recent gains in vaccination coverage, pre-existing immunity to dengue virus is abundant in the human population, and secondary dengue infections are common. Here, we contrast the mechanisms initiating and sustaining adaptive immune responses during primary infection with the immune pathways that are pre-existing and reactivated during secondary dengue. We also discuss new developments in our understanding of the contributions of CD4

Indexed as

Adaptive ImmunityAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDengueDengue VaccinesDengue VirusHumansDengue Vaccines

Identifiers

PMID30679808
OpenAlexW2911741918

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.