Evidence map›Paper›PMID 30679766›Full record

ArticleScientific reports2019

Mitochondrial haplogroups are not associated with diabetic retinopathy in a large Australian and British Caucasian sample.

Ebony Liu, Georgia Kaidonis, Mark C Gillies, Sotoodeh Abhary, Rohan W Essex, John H Chang, Bishwanath Pal, Mark Daniell, Stewart Lake, Jolly Gilhotra and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 9 institutions in 3 countries.

Ebony LiuDepartment of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia. ebony.liu@flinders.edu.au.
Georgia KaidonisDepartment of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia.
Mark C GilliesSave Sight Institute, Clinical Ophthalmology and Eye Health, the University of Sydney, Sydney, New South Wales, Australia.
Sotoodeh AbharyDepartment of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia.
Rohan W EssexAcademic Unit of Ophthalmology, Australian National University, Canberra, Australia.ORCID 0000-0001-5323-0334
John H ChangSchool of Medical Sciences, University of NSW, Sydney, New South Wales, Australia.
Bishwanath PalMedical Retina Service, Moorfields Eye Hospital, London, United Kingdom.
Mark DaniellDepartment of Ophthalmology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Stewart LakeDepartment of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia.
Jolly GilhotraDepartment of Ophthalmology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Nikolai PetrovskyDepartment of Endocrinology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia.ORCID 0000-0002-1580-5245
Alex W HewittCentre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-5123-5999
Alicia JenkinsNHMRC Clinical Trials Centre, University of Sydney, Camperdown, New South Wales and St Vincent's Hospital, Fitzroy, Victoria, Australia.
Ecosse L LamoureuxCentre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia.
Jonathan M GleadleDepartment of Renal Medicine, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.ORCID 0000-0002-5215-7208
Kathryn P BurdonDepartment of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia.ORCID 0000-0001-8217-1249
Jamie E CraigDepartment of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia.
Flinders University · AUThe University of Melbourne · AUThe University of Sydney · AUAustralian National University · AUMoorfields Eye Hospital · GBRoyal Adelaide Hospital · AUThe Royal Melbourne Hospital · AUUniversity of Tasmania · AUUNSW Sydney · AU

Funding

Department of Health
6 · The paper itself

Abstract

Mitochondrial haplogroups H1, H2 and UK have previously been reported to be associated with proliferative diabetic retinopathy (PDR) in Caucasian patients with diabetes. We aimed to replicate this finding with a larger sample and expand the analysis to include different severities of DR, and diabetic macular edema (DME). Caucasian participants (n = 2935) with either type 1 or type 2 diabetes from the Australian Registry of Advanced Diabetic Retinopathy were enrolled in this study. Twenty-two mitochondrial single nucleotide polymorphisms were genotyped by MassArray and haplogroups reconstructed using Haplogrep. Chi square tests and logistic regressions were used to test associations between haplogroup and DR phenotypes including any DR, non-proliferative DR (NPDR), proliferative DR (PDR) and DME. After stratifying the samples in type 1 and type 2 diabetes groups, and adjusting for sex, age, diabetes duration, concurrent HbA1c and hypertension, neither haplogroups H1, H2, UK, K or JT were associated with any DR, NPDR, PDR or DME.

Indexed as

AdolescentAdultAgedAged, 80 and overAustraliaCase-Control StudiesDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic RetinopathyFemaleGenotypeGlycated HemoglobinHumansMacular EdemaMaleMiddle AgedGlycated Hemoglobin

Identifiers

PMID30679766
PMCPMC6345891
OpenAlexW2911709241

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.